Paragonimiasis Clinical Presentation

Updated: Oct 11, 2019
  • Author: Seth D Rosenbaum, MD; Chief Editor: Russell W Steele, MD  more...
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About 20% of patients with paragonimiasis are asymptomatic. Abdominal pain, diarrhea, and urticaria occur during the acute phase, which corresponds to the period of invasion and migration of immature flukes. These initial symptoms are followed a few days later by fever, cough, dyspnea, chest pain, malaise, and sweats. The acute phase usually persists for several weeks. During the chronic phase, manifestations may be pulmonary or extrapulmonary. Chronic pulmonary symptoms consist of dry cough followed by a cough productive of tenacious and rusty or golden sputum. Pulmonary symptoms begin approximately 6 months after infection and are often mistaken for symptoms of tuberculosis (TB). The American College of Chest Physicians has established clinical practice guidelines for chronic due to TB and other infections. [6]

Eosinophilia and lack of fever suggest the true diagnosis. Peripheral eosinophilia is present in as many as 25% of patients. [7] Patients frequently report vague chest discomfort, dyspnea on exertion, or wheezing. Life-threatening hemoptysis may occur in some cases. Extrapulmonary paragonimiasis can be divided into cerebral, abdominal, subcutaneous, and miscellaneous forms of the disease. [8]

Extrapulmonary paragonimiasis can occur either from the migration of young or mature flukes to various organs or from eggs that enter the circulation and are carried to the following sites:

  • Liver
  • Spleen
  • Kidney
  • Brain
  • Intestinal wall
  • Peritoneum
  • Mesenteric lymph nodes
  • Muscle
  • Testis/ovary
  • Subcutaneous tissues
  • Spinal cord

Although cerebral paragonimiasis occurs in fewer than 1% of symptomatic patients, it is the most common extrapulmonary site of infection and is responsible for 50% of all extrapulmonary disease. [1] Moreover, it is seen in as many as 25% of patients requiring hospitalization. This form of the disease is also particularly common in children. Early symptoms resemble meningoencephalitis and may persist 1-2 months. Chronic phase symptoms include headache, vomiting, seizures, or weakness.

Eggs and worms may also cause surrounding cysts, abscesses, or granulomas to form. Cysts may occur in the intestinal wall, liver, spleen, abdominal wall, peritoneal cavity, or mesenteric lymph nodes. Symptoms may include bloody diarrhea or abdominal pain.

Xia et al conducted a retrospective analysis of clinical characteristics and treatment of recently diagnosed cases of cerebral paragonimiasis. [9] Their study cohort consisted of 27 patients who were diagnosed between September 2008 and September 2013. These diagnoses were confirmed by IgG enzyme-linked immunosorbent assays. Follow-up was performed for 24 patients during a period of 6 to 56 months. Cerebral paragonimiasis accounted for 27 of 125 cases (21.6%) of paragonimiasis. The average duration from onset to treatment with praziquantel was 69 days. All patients resided in rural areas. Positive lung results were found in 20 patients; of these patients, visible lung lesions were found in 14. The lesions were surgically removed in 8 of these cases. High eosinophil counts were found in 24 patients, and eosinophilic meningitis was noted in 17. The rate of misdiagnosis and missed diagnosis was 30.4%. Most symptoms markedly improved aftertreatment, but mild movement disorders in conjunction with impaired memory and personality changes persisted in a small number of patients. The investigators advised that clinicians be alert to the possibility of cerebral paragonimiasis in young patients (aged 4-16 years) who have primary symptoms of epilepsy and hemorrhage. Liquid-based cytologic examination of cerebral spinal fluid and peripheral blood eosinophil counts can aid in differentiating cerebral paragonimiasis from similar diseases. [9]


Physical Examination

Physical findings are usually not impressive in pulmonary paragonimiasis, but they may include findings described below.

Clubbing of the fingers occasionally occurs.

Lungs are normally clear but rales, egophony, or dullness to percussion may occur with complications such as pneumonia or pleural effusion.

Cough begins as dry and progresses to productive with blood-tinged sputum. [1] The late clinical picture is similar to chronic bronchitis or bronchiectasis with profuse expectoration, pleuritic chest pain, dyspnea, cough, and occasional hemoptysis.

Signs of cerebral paragonimiasis include facial palsy, hemiplegia, seizures, and paraplegia.

Ocular signs include impaired visual acuity because of optic atrophy, papilledema, and hemianopsia.

Spinal involvement may produce monoplegia, paraplegia, lower extremity paresthesias, or sensory loss.

Findings in cases of abdominal involvement may include palpable masses.

Hematuria may be observed with kidney involvement, and eggs may sometimes be detected in the urine.

Patients with subcutaneous paragonimiasis can present with migratory swelling or subcutaneous nodules containing immature flukes. These firm, mobile, and tender subcutaneous nodules are often found in the lower abdominal and inguinal region.

Scrotal paragonimiasis may mimic epididymitis or an incarcerated hernia.



Pulmonary complications include pneumonia, bronchitis, bronchiectasis, lung abscess, pleural effusion, and empyema.

Cerebral complications include seizures and coma.

Skin complications include migratory allergic skin lesions.