Renal Glucosuria Workup

Updated: Dec 10, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Laboratory Studies

The following studies are indicated in renal glucosuria:

  • Urinalysis with microscopic analysis

  • Fasting blood glucose concentration

  • Serum electrolyte, bicarbonate, phosphorus, and uric acid levels

  • Glycosylated hemoglobin levels

  • A 24-hour urine collection for amino acids when other tubular abnormalities are present

  • Fractional excretion of phosphorus (< 15%), uric acid (< 15%, or uric acid per dL glomerular filtration rate [GFR] < 0.55), sodium (normal limit [NL] approximately 1-3%), potassium (< 25%), bicarbonate (NL < 15%)


Histologic Findings

To date, no direct evidence of SGLT2 heterozygous mutations in kidney tissue has been obtained. [41]