Congenital Pneumonia Differential Diagnoses

Updated: Mar 01, 2016
  • Author: Muhammad Aslam, MD; Chief Editor: Ted Rosenkrantz, MD  more...
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Diagnostic Considerations

Although many cases of pneumonia diagnosed in the first 24 hours of life are infectious and benefit from targeted antimicrobial therapy, some are noninfectious.

A number of conditions may present as respiratory dysfunction in the first 24 hours of life. However, consider that a newborn with any of these conditions may have superimposed pneumonia as well. Such conditions include the following:

  • Alveolar-capillary dysplasia

  • Arrhythmia

  • Asphyxia

  • Bronchial duplication

  • Chest wall injury or anomaly

  • Choanal atresia

  • Chylothorax

  • Diaphragmatic eventration

  • Heart block

  • Intracranial hemorrhage

  • Laryngeal cleft

  • Laryngeal nerve injury

  • Mutation of ABCA3 gene (for surfactant phospholipid transport)

  • Neuromuscular disorders

  • Phrenic nerve injury

  • Pulmonary hemorrhage

  • Pulmonary hypoplasia

  • Pulmonary lymphangiectasia

  • Spinal injury

  • Surfactant-related protein B deficiency

  • Tachycardia syndromes

  • Tracheoesophageal fistula [25]

  • Transplacental medications

  • Vascular catheter accident

  • Other causes of airway obstruction

  • Other congenital heart diseases

  • Other inborn errors of metabolism

  • Other neuromuscular diseases

Differential Diagnoses