Pediatric Human Metapneumovirus Treatment & Management

1. van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001 Jun. 7(6):719-24. [QxMD MEDLINE Link].

2. Haynes AK, Fowlkes AL, Schneider E, Mutuc JD, Armstrong GL, Gerber SI. Human Metapneumovirus Circulation in the United States, 2008 to 2014. Pediatrics. 2016 May. 137 (5):[QxMD MEDLINE Link].

3. Walsh EE, Peterson DR, Falsey AR. Human metapneumovirus infections in adults: another piece of the puzzle. Arch Intern Med. 2008 Dec 8. 168(22):2489-96. [QxMD MEDLINE Link].

4. Garbino J, Soccal PM, Aubert JD, Rochat T, Meylan P, Thomas Y. Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults. Thorax. 2009 Jan 27. [QxMD MEDLINE Link].

5. Kamboj M, Gerbin M, Huang CK, Brennan C, Stiles J, Balashov S. Clinical characterization of human metapneumovirus infection among patients with cancer. J Infect. 2008 Dec. 57(6):464-71. [QxMD MEDLINE Link].

6. Falsey AR, Dallal GE, Formica MA, Andolina GG, Hamer DH, Leka LL. Long-term care facilities: a cornucopia of viral pathogens. J Am Geriatr Soc. 2008 Jul. 56(7):1281-5. [QxMD MEDLINE Link].

7. Falsey AR. Human metapneumovirus infection in adults. Pediatr Infect Dis J. 2008 Oct. 27(10 Suppl):S80-3. [QxMD MEDLINE Link].

8. Stempel HE, Martin ET, Kuypers J, Englund JA, Zerr DM. Multiple viral respiratory pathogens in children with bronchiolitis. Acta Paediatr. 2009 Jan. 98(1):123-6. [QxMD MEDLINE Link].

9. Paranhos-Baccala G, Komurian-Pradel F, Richard N, Vernet G, Lina B, Floret D. Mixed respiratory virus infections. J Clin Virol. 2008 Dec. 43(4):407-10. [QxMD MEDLINE Link].

10. Jain S, Williams DJ, Arnold SR, et al, CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015 Feb 26. 372 (9):835-45. [QxMD MEDLINE Link]. [Full Text].

11. Boivin G, De Serres G, Hamelin ME, et al. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin Infect Dis. 2007 May 1. 44(9):1152-8. [QxMD MEDLINE Link].

12. Adams O, Weis J, Jasinska K, Vogel M, Tenenbaum T. Comparison of human metapneumovirus, respiratory syncytial virus and Rhinovirus respiratory tract infections in young children admitted to hospital. J Med Virol. 2015 Feb. 87 (2):275-80. [QxMD MEDLINE Link].

13. Spyridaki IS, Christodoulou I, de Beer L, Hovland V, Kurowski M, Olszewska-Ziaber A. Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN project. J Virol Methods. 2009 Mar. 156(1-2):102-6. [QxMD MEDLINE Link].

14. Butt SA, Maceira VP, McCallen ME, Stellrecht KA. Comparison of three commercial RT-PCR systems for the detection of respiratory viruses. J Clin Virol. 2014 Nov. 61 (3):406-10. [QxMD MEDLINE Link].

15. Rogers BB, Shankar P, Jerris RC, Kotzbauer D, Anderson EJ, Watson JR, et al. Impact of a rapid respiratory panel test on patient outcomes. Arch Pathol Lab Med. 2015 May. 139 (5):636-41. [QxMD MEDLINE Link]. [Full Text].

16. Hilmes MA, Daniel Dunnavant F, Singh SP, Ellis WD, Payne DC, Zhu Y, et al. Chest radiographic features of human metapneumovirus infection in pediatric patients. Pediatr Radiol. 2017 Dec. 47 (13):1745-1750. [QxMD MEDLINE Link].

17. [Guideline] Bronchiolitis in children. A national clinical guideline. Scottish Intercollegiate Guidelines Network (SIGN). 2006 Nov. [Full Text].

18. Doan QH, Kissoon N, Dobson S, et al. A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnesses. J Pediatr. 2009 Jan. 154(1):91-5. [QxMD MEDLINE Link].

19. Hamelin ME, Boivin G. Development and validation of an enzyme-linked immunosorbant assay for human metapneumovirus serology based on recombinant viral protein. Clin Diag Lab Immunol. 2005. 12:249-53. [QxMD MEDLINE Link].

20. Kuypers J, Wright N, Corey L, Morrow R. Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCR. J Clin Virol. 2005. 33:299-305. [QxMD MEDLINE Link].

21. Nissen MD, Siebert DJ, Mackay IM, Sloots TP, Withers SJ. Evidence of human metapneumovirus in Australian children. Med J Aust. 2002 Feb 18. 176(4):188. [QxMD MEDLINE Link].

22. Percivalle E, Sarasini A, Visai L, Revello MG, Gerna G. Rapid detection of human metapneumovirus strains in nasopharyngeal aspirates and shell vial cultures by monoclonal antibodies. J Clin Microbiol. 2005 Jul. 43(7):3443-6. [QxMD MEDLINE Link]. [Full Text].

23. Robinson JL, Lee BE, Bastien N, Li Y. Seasonality and clinical features of human metapneumovirus infection in children in Northern Alberta. J Med Virol. 2005. 76:98-105. [QxMD MEDLINE Link].

24. Schildgen O, Glatzel T, Geikowski T, et al. Human metapneumovirus RNA in encephalitis patient. Emerg Infect Dis. 2005 Mar. 11(3):467-70. [QxMD MEDLINE Link].

25. Suzuki A, Watanabe O, Okamoto M, et al. Detection of human metapneumovirus from children with acute otitis media. Pediatric Infectious Disease Journal. 2005. 24:655-7. [QxMD MEDLINE Link].

26. Tu CC, Chen LK, Lee YS, Ko CF, Chen CM, Yang HH. An outbreak of human metapneumovirus infection in hospitalized psychiatric adult patients in Taiwan. Scand J Infect Dis. 2009 Mar 23. 1-5. [QxMD MEDLINE Link].

27. Williams JV, Martino R, Rabella N, et al. A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. Journal of Infectious Diseases. 2005. 192:1061-5. [QxMD MEDLINE Link].

Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University

Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Phi Beta Kappa

Disclosure: Received research grant from: Pfizer;GlaxoSmithKline;AstraZeneca;Merck;American Academy of Pediatrics, Novavax, Regeneron, Diassess, Actelion<br/>Received income in an amount equal to or greater than $250 from: Sanofi Pasteur.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Russell W Steele, MD Clinical Professor, Tulane University School of Medicine; Staff Physician, Ochsner Clinic Foundation

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, Southern Medical Association

Disclosure: Nothing to disclose.

Itzhak Brook, MD, MSc Professor, Department of Pediatrics, Georgetown University School of Medicine

Itzhak Brook, MD, MSc is a member of the following medical societies: American Association for the Advancement of Science, American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, Association of Military Surgeons of the US, Infectious Diseases Society of America, International Immunocompromised Host Society, International Society for Infectious Diseases, Medical Society of the District of Columbia, New York Academy of Sciences, Pediatric Infectious Diseases Society, Society for Experimental Biology and Medicine, Society for Pediatric Research, Southern Medical Association, Society for Ear, Nose and Throat Advances in Children, American Federation for Clinical Research, Surgical Infection Society, Armed Forces Infectious Diseases Society

Disclosure: Nothing to disclose.

Leslie L Barton, MD Professor Emerita of Pediatrics, University of Arizona College of Medicine

Leslie L Barton, MD is a member of the following medical societies: American Academy of Pediatrics, Association of Pediatric Program Directors, Infectious Diseases Society of America, and Pediatric Infectious Diseases Society

Disclosure: Nothing to disclose.

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