Pediatric Viral Hemorrhagic Fevers Treatment & Management

Updated: Aug 17, 2021
  • Author: Martha L Muller, MD, MPH; Chief Editor: Russell W Steele, MD  more...
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Medical Care

Early diagnosis and supportive care can be lifesaving for most patients with viral hemorrhagic fever (VHF). The cornerstone of therapy for all these infections is judicious fluid and electrolyte management.

Blood, platelet, and plasma replacement may be useful for Crimean-Congo hemorrhagic fever (CCHF). High-dose corticosteroids, immune globulin intravenous, and fresh frozen plasma have also been reported to be successful in CCHF. [41] Infusion of convalescent plasma during the first 8 days of illness with Argentine HF reduces the mortality rate from 15-30% to less that 1%.

Novel treatment studies using positively-charged phosphorodiamidate morpholino oligomers (PMOplus) demonstrate protection of monkeys infected with Ebola and Marburg viruses. [42] These studies suggest a potential therapeutic modality for human infection for the future.

Studies of high-dose mannose-binding lectin therapy in mice suggest a promising future therapeutic modality for Ebola (and other viruses) infection. [43, 44]



See the list below:

  • Infectious diseases specialist (urgent)

  • Hematologist

  • Others as dictated by the clinical circumstances