Consumption Coagulopathy Treatment & Management

Updated: Mar 28, 2022
  • Author: Himal M Shah, MBBS, MD, DM; Chief Editor: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK)  more...
  • Print

Medical Care

The most important concept in disseminated intravascular coagulation (DIC) is that it is a secondary manifestation of an underlying disorder.

The most important therapeutic maneuver is treating the initiating disorder. Without this, supportive measures will ultimately fail.

Shock is a frequent underlying factor, and important supportive measures include ventilatory support, volume support, blood product administration, adequate antibiotic therapy, pressor support, and close monitoring of neurologic and renal function. Dialysis may be required in critical cases..


Surgical Care

Involve a pediatric surgeon as the underlying disorder indicates.

Surgical complications may include thrombotic occlusion of an artery with imminent loss of limb or organ function, bleeding, or compartment syndrome.

DIC can result in bleeding at any surgical site.



DIC is a complex pediatric disease that is best treated in tertiary care centers by using a multidisciplinary approach. Involving many services may be appropriate.


Treatment involves complex decisions regarding differential diagnosis and treatment options.

Involve a pediatric hematologist early.

If DIC is thought to be secondary to malignancy, a pediatric oncologist can expedite diagnosis.


Most children with DIC are critically ill and require monitoring that is only available in the pediatric ICU.

Many children experience shock and respiratory failure and require ventilatory support.

Blood bank specialist

Treatment of patients may involve blood products.

Blood bank specialists can provide resource advice on treatment decisions.

Infectious disease specialist

Many children with DIC have underlying sepsis that requires aggressive management.


Renal derangement is not uncommon because thrombosis and shock interfere with renal perfusion.


DIC may cause neurologic symptoms related to CNS thrombosis, infarction, or hemorrhage. [28]