Aicardi Syndrome Medication

Updated: Nov 30, 2018
  • Author: Ravi Sunderkrishnan, MD; Chief Editor: Maria Descartes, MD  more...
  • Print

Medication Summary

Multiple medications are available to treat infantile spasm, the most common initial epileptic manifestation of Aicardi syndrome. Initiate a detailed discussion with the family about the available medications. Individualize treatment to best suit the patient and the capabilities and wishes of the family.


Anticonvulsant agents

Class Summary

Effective management requires a detailed and accurate classification of seizure types.

Corticotropin (ACTH, Acthar)

Precise mechanism for infantile spasms unknown. Theorized that ACTH suppresses corticotropin-releasing hormone (CRH), which is an excitatory neuropeptide. Infants with infantile spasms may have increased CRH.

Vigabatrin (Sabril)

Currently not approved by FDA, and benefits of successful treatment of infantile spasm must be weighed against potentially serious ophthalmologic complications. May be obtained as an orphan drug from Aventis Pharmaceuticals for infantile spasm. Synthetic derivative of GABA.