Neonatal Hemochromatosis Differential Diagnoses

Updated: Oct 20, 2017
  • Author: Ann M Simonin, MD, FAAP; Chief Editor: Carmen Cuffari, MD  more...
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DDx

Diagnostic Considerations

When liver failure is diagnosed in the first 1-2 days of life, neonatal hemochromatosis is by far the most common diagnosis. Afterward, many other conditions can manifest and must be excluded. They include all other causes of hepatic failure, including infective, metabolic, and hemorrhagic causes.

The following are other causes of liver failure in the newborn:

  • Antenatal infection with adenovirus

  • Coxsackievirus

  • Alpha1-antitrypsin (A1At) deficiency

  • Hereditary fructose intolerance

  • Maternofetal blood group incompatibility

  • Hemoglobinopathy

  • Hemophagocytic syndrome

  • Inborn defects in erythrocyte membrane or enzymes

  • Sepsis

  • Ischemia or abnormal perfusion

  • Extrahepatic biliary atresia

  • Hepatic infarct

  • Congenital leukemia

All infants with a diagnosis of liver failure should undergo testing until a final diagnosis is reached.

Failure to diagnose neonatal hemochromatosis, resulting in the family having subsequent children with the same diagnosis, could result in legal actions against the physician.

Differential Diagnoses