Gianotti-Crosti Syndrome Workup

Updated: Oct 09, 2020
  • Author: Sören A Craig-Müller, MD; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

In general, no laboratory studies are needed in patients with Gianotti-Crosti syndrome (GCS). Jaundice or hepatomegaly should prompt a search for the hepatitis B virus and elevated levels of liver enzymes. However, elevated levels of liver enzymes are most likely related to Epstein-Barr virus infection.



A skin biopsy may be performed to rule out other diseases in the differential diagnosis.


Histologic Findings

Skin biopsy findings are nonspecific and are more helpful in ruling out other diseases. The epidermis shows focal spongiosis, parakeratosis, mild acanthosis, and psoriasiform epidermal hyperplasia. [5]  The upper dermis has a moderately intense perivascular infiltrate of lymphocytes and histiocytes with occasional scattered eosinophils. [19] Extravasated erythrocytes can be found in the papillary dermis. [15]