Medical Care
Gianotti-Crosti syndrome (GCS) is a benign self-limited condition that requires no treatment. Topical steroids are generally not effective, although anecdotal responses have been reported. Systemic treatment with antihistamines has been moderately helpful in relieving pruritus.
Also see Dermatologic Manifestations of Gianotti-Crosti Syndrome.
Consultations
Consultation with a dermatologist or a pediatric dermatologist should be sought in confusing cases.
Consultation with a pediatric gastroenterologist should be sought for the rare cases associated with the hepatitis B virus.
Activity
Activity is limited only by symptoms. The infectious period ends when the exanthem appears; therefore, the patient may participate in daycare or school at this time.
Long-Term Monitoring
No specific follow-up is necessary for uncomplicated cases of Gianotti-Crosti syndrome (GCS); however, transaminase elevations, if present, should be monitored until normalization.
GCS associated with hepatitis B infection has an increased incidence of a carrier state compared with hepatitis B infection alone. In this instance, some suggest monitoring the surface antigen as an indicator of potential infectivity.
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Multiple erythematous flat-topped papules on the cheeks of an 18-month-old boy with Gianotti-Crosti syndrome.
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Arm of a 3-year-old boy with Gianotti-Crosti syndrome demonstrating well-defined erythematous lichenoid papules on the arm and forearm.
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Thigh of the 3-year-old boy with Gianotti-Crosti syndrome.
