Gianotti-Crosti Syndrome Treatment & Management

Updated: Oct 09, 2020
  • Author: Sören A Craig-Müller, MD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Gianotti-Crosti syndrome (GCS) is a benign self-limited condition that requires no treatment. Topical steroids are generally not effective, although anecdotal responses have been reported. Systemic treatment with antihistamines has been moderately helpful in relieving pruritus.

Also see Dermatologic Manifestations of Gianotti-Crosti Syndrome.



Consultation with a dermatologist or a pediatric dermatologist should be sought in confusing cases.

Consultation with a pediatric gastroenterologist should be sought for the rare cases associated with the hepatitis B virus.



Activity is limited only by symptoms. The infectious period ends when the exanthem appears; therefore, the patient may participate in daycare or school at this time.


Long-Term Monitoring

No specific follow-up is necessary for uncomplicated cases of Gianotti-Crosti syndrome (GCS); however, transaminase elevations, if present, should be monitored until normalization.

GCS associated with hepatitis B infection has an increased incidence of a carrier state compared with hepatitis B infection alone. In this instance, some suggest monitoring the surface antigen as an indicator of potential infectivity.