Tetralogy of Fallot With Pulmonary Atresia Differential Diagnoses

Updated: Dec 22, 2020
  • Author: Michael D Pettersen, MD; Chief Editor: Howard S Weber, MD, FSCAI  more...
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Diagnostic Considerations

Because inadequate collaterals (major aortopulmonary collateral arteries [MAPCAs]) may produce hypoxemia too severe for survival for newborn infants with closure of the ductus arteriosus, early recognition of tetralogy of Fallot with pulmonary atresia (TOF-PA) is critical.

Associated syndromes and extracardiac malformations are not uncommon in patients with TOF-PA (see Etiology). Thus, also consider conditions such as asplenia and polysplenia heterotaxy, double-outlet right ventricle with severe pulmonary stenosis or atresia, and single ventricle with severe pulmonary stenosis or atresia.

Differential Diagnoses