Transient Hypogammaglobulinemia of Infancy Follow-up

Updated: Aug 06, 2019
  • Author: Alan P Knutsen, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Further Outpatient Care

Confirm initial diagnosis by measuring serum immunoglobulin levels annually until levels normalize.

As discussed above, treatment of infections and modalities to reduce infections should be instituted. Treatment of allergic disorders should also be instituted.

With appropriate treatment, these children can be considered healthy. The prognosis for transient hypogammaglobulinemia of infancy (THI) is quite good. Most children outgrow this immune deficiency when aged 2–6 years. However, THI is a diagnosis that is made retrospectively when serum immunoglobulin levels normalize and all antibody responses are normal.

The immune system is periodically evaluated, usually at yearly intervals.