Leukocyte Adhesion Deficiency Questions & Answers

Updated: Oct 09, 2019
  • Author: Stephen J Nervi, MD; Chief Editor: Harumi Jyonouchi, MD  more...
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Questions & Answers

Overview

What is leukocyte adhesion deficiency?

What is leukocyte adhesion deficiency type I?

What is leukocyte adhesion deficiency type II?

What are the leukocyte adhesion deficiency variants?

What is the pathophysiology of leukocyte adhesion deficiency?

What is the US prevalence of leukocyte adhesion deficiency?

What is the global prevalence of leukocyte adhesion deficiency?

What is the mortality and morbidity associated with leukocyte adhesion deficiency?

What are the racial predilections of leukocyte adhesion deficiency?

What are the sexual predilections of leukocyte adhesion deficiency?

At what age is leukocyte adhesion deficiency typically diagnosed?

Presentation

Which clinical history findings are characteristic of leukocyte adhesion deficiency type II?

Which clinical history findings are characteristic of leukocyte adhesion deficiency type I?

Which physical findings are characteristic of leukocyte adhesion deficiency type II?

Which physical findings are characteristic of leukocyte adhesion deficiency type I?

What causes leukocyte adhesion deficiency?

DDX

How are leukocyte adhesion deficiencies differentiated from hyperimmunoglobulin E syndrome or chronic granulomatous disease?

How are leukocyte adhesion deficiencies differentiated from a defect in a guanosine triphosphate (GTP)-binding protein, Rac2?

How are infants with leukocyte adhesion deficiencies differentiated from healthy infants?

Workup

What is the role of lab tests in the workup of leukocyte adhesion deficiency?

How prevalent is preimplantation genetic diagnosis (PGD) of leukocyte adhesion deficiency?

What is the role of CT scanning and MRI in the workup of leukocyte adhesion deficiency?

What is the role of bone scanning in the workup of leukocyte adhesion deficiency?

Which lymphocyte or antibody findings are characteristic of leukocyte adhesion deficiency?

Which invasive procedures are used in the workup of leukocyte adhesion deficiency?

Which histologic findings are characteristic of leukocyte adhesion deficiency?

Treatment

How is leukocyte adhesion deficiency treated?

What is the role of surgery in the treatment of leukocyte adhesion deficiency?

Which specialist consultations are beneficial to patients with leukocyte adhesion deficiency?

Which dietary modifications are used in the treatment of leukocyte adhesion deficiency?

Which activity modifications are used in the treatment of leukocyte adhesion deficiency?

Medications

What is the role of medications in the treatment of leukocyte adhesion deficiency?

Follow-up

What is included in the long-term monitoring of leukocyte adhesion deficiency?

When is inpatient care indicated for leukocyte adhesion deficiency?

What causes fungal infections in patients with leukocyte adhesion deficiency?

When is patient transfer indicated for the treatment of leukocyte adhesion deficiency?

How is leukocyte adhesion deficiency diagnosed prenatally?

What are the possible complications of leukocyte adhesion deficiency?

What is the prognosis of leukocyte adhesion deficiency?

What is included in patient education about leukocyte adhesion deficiency?