Pediatric Dehydration Medication

Updated: Nov 12, 2018
  • Author: Alex Koyfman, MD; Chief Editor: Muhammad Waseem, MBBS, MS, FAAP, FACEP, FAHA  more...
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Class Summary

Use a single dose of oral ondansetron in combination with oral rehydration for patients with dehydration, nausea, and vomiting. [12, 15, 16] However, the use of an antiemetic should not shift the focus away from adequate fluid resuscitation.

As dopamine antagonists, these agents are effective in treating nausea and vomiting. They also may act as prokinetics to increase gastric motility and enhance absorption.

In a double-blind, randomized, placebo-controlled trial of children under age 5 years with acute diarrhea with vomiting and some dehydration, Danewa et al found that oral rehydration was improved by administration of a single oral dose of ondansetron prior to the start of oral rehydration therapy. [19]

Ondansetron (Zofran, Zuplenz)

Odansetron is a selective 5-HT3-receptor antagonist that blocks serotonin both peripherally and centrally. It prevents nausea and vomiting.