Condyloma Acuminatum (Genital Warts) Follow-up

Updated: Sep 30, 2020
  • Author: Delaram Ghadishah, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Further Outpatient Care

Patient should have a follow-up visit with OB/GYN (female) or with urology (male) within 1 week. Treat patient using medications and, if ineffective, with cryotherapy, curettage, electrodesiccation, surgical excision, carbon dioxide laser treatment, or combination therapy. Evaluate and treat sexual partner(s). Perform workup for human papillomavirus (HPV) and other sexually transmitted diseases (STDs).

Search for immunosuppression in patients with treatment failures and recurrences.

Look for biopsy recurrences and treatment failures.


Further Inpatient Care

Generally, no further inpatient care is necessary unless the patient has malignant transformation of lesions to carcinoma.


Inpatient & Outpatient Medications

Podofilox (purified podophyllotoxin) is available for home use by the patient.



No medications or vaccines are 100% effective. One human papillomavirus vaccine (9-valent, Gardasil 9) is available in the United States for the prevention of HPV-associated neoplasias and dysplasias, including genital warts (condylomata acuminata). The FDA has expanded the age to receive the vaccine through age 45 years. [7]

Sexual abstinence and monogamy are protective.

Condoms may discourage transmission.



See the list below:

  • Local disfigurement

  • Transformation to genitourinary malignancies in both males and females [8]

  • Transmission to neonate or partners

  • Recurrence of condyloma acuminatum



Many patients either fail to respond to treatment, or condyloma acuminatum recurs after adequate response.

Recurrence rate of cervical dysplasia in women is not altered by treatment of sexual partners.

Recurrence rates exceed 50% after 1 year and have been attributed to the following:

  • Repeat infection from sexual contact

  • Long incubation period of HPV

  • Location of virus in superficial skin layers away from lymphatics

  • Persistence of virus in surrounding skin, hair follicles, or sites not adequately reached by intervention used

  • Missed or deep lesions

  • Subclinical lesions

  • An underlying immunosuppression


Patient Education

Identify and educate individuals at risk for condyloma acuminatum.

For excellent patient education resources, visit eMedicineHealth's Sexual Health Center. Also, see eMedicineHealth's patient education article Genital Warts (HPV Infection).