Hypophosphatemia in Emergency Medicine Follow-up

Updated: Dec 10, 2021
  • Author: Alex Koyfman, MD; Chief Editor: Erik D Schraga, MD  more...
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Further Inpatient Care

Patients with severe or symptomatic hypophosphatemia should be admitted for IV replacement therapy.

Since isolated phosphate deficiency is extremely unlikely, these patients invariably have a comorbid reason for admission.

Equilibration of IV with intracellular phosphate usually leads to recurrence of hypophosphatemia, making periodic monitoring and replacement necessary over the ensuing 2 days.

A rational approach to IV phosphate replacement is to administer a predefined amount of phosphate, then reevaluate the resulting serum phosphate level every 6 hours to guide further treatment.