Scleroderma Differential Diagnoses

Updated: Feb 03, 2022
  • Author: Sergio A Jimenez, MD, MACR, FACP, FRCP(UK Hon); Chief Editor: Herbert S Diamond, MD  more...
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Diagnostic Considerations

The following disorders may present clinical similarities with systemic sclerosis (“scleroderma mimics”) and need to be included in the differential diagnosis: [101, 102, 103, 104]

Gadolinium-based contrast agents, bleomycin, pentazocine, and several other drugs and chemicals have been shown to cause disorders resembling systemic sclerosis. These must be considered in the differential diagnosis.