Hereditary Spastic Paraplegia Differential Diagnoses

Updated: Jun 11, 2021
  • Author: Nam-Jong Paik, MD, PhD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Diagnostic Considerations

Failure to rule out reversible forms of spinal cord lesions (mechanical cord compression or spinal cord tumor) when considering a diagnosis of hereditary spastic paraplegia (HSP) invites problems.

Conditions to consider in the differential diagnosis of HSP include the following:

  • Hereditary motor-sensory neuropathy type 5

  • Spondylosis

  • Atlantoaxial canal stenosis

  • Arteriovenous malformation compressing spinal cord

  • Arnold-Chiari syndrome

  • Tethered cord

  • Neoplasm

  • Granuloma

  • Spinocerebellar ataxias

  • Adrenomyeloneuropathy

  • Deficiency of vitamins B-12 and E

  • Abetalipoproteinemia

  • Mitochondrial disorders

  • Human T-cell lymphocytotrophic virus infection

  • Toxins

  • Stiff-limb syndrome

Differential Diagnoses