Lymphomatoid Granulomatosis Follow-up

Updated: Dec 31, 2015
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Transformation into high-grade lymphoma may occur (13-47%).

Progressive respiratory disease with increasing respiratory failure may result in pneumothorax, infection, and hemorrhage.

Hemoptysis, occasionally massive, may complicate cavitation of the diseased pulmonary tissue.

Pneumothorax may occur.

Opportunistic infections may develop.

Seizures, mental status changes, mononeuropathy, or diabetes insipidus may complicate progressive neurological disease.



The median survival from diagnosis is 14 months. More than 60% of patients die within 5 years.

The cause of death is usually extensive destruction of the pulmonary parenchyma, resulting in respiratory failure, sepsis, and, occasionally, massive hemoptysis.

Poor prognostic indicators include an age younger than 30 years, neurological or hepatic involvement, leukopenia or pancytopenia, and anergy.