Extrapulmonary Small Cell Carcinoma Differential Diagnoses

Updated: Jun 11, 2021
  • Author: Irfan Maghfoor, MD; Chief Editor: Nagla Abdel Karim, MD, PhD  more...
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Diagnostic Considerations

Pathologically, extrapulmonary small cell carcinoma (EPCC) needs to be differentiated from other tumors composed of small round blue cells under light microscopy, including the following:

  • Lymphoma
  • Rhabdomyosarcoma
  • Carcinoids

EPSCC is distinguished from metastatic pulmonary small cell carcinoma with chest imaging. Additional workup with sputum cytology, bronchoscopy, or biopsy should be conducted for indeterminate pulmonary findings. [9]

Differential Diagnoses