Kaposi Sarcoma Differential Diagnoses

Updated: Feb 15, 2022
  • Author: Jessica Katz, MD, PhD; Chief Editor: Edwin Choy, MD, PhD  more...
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Diagnostic Considerations

Bacillary angiomatosis is often difficult to distinguish clinically from Kaposi sarcoma. It is caused by Rochalimaea species, a slow-growing, fastidious, gram-negative bacillus that is readily treated with antibiotics. Bacillary angiomatosis lesions typically possess capillary proliferation and neutrophilic inflammation. In contrast, Kaposi sarcoma lesions display slitlike vascular spaces containing lymphoplasmacytic infiltrates. A skin biopsy is required to establish diagnosis.

Other problems to consider in the differential diagnosis include the following:

Differential Diagnoses