Rickettsialpox Treatment & Management

Updated: Jun 03, 2020
  • Author: Darvin Scott Smith, MD, MSc, DTM&H; Chief Editor: John L Brusch, MD, FACP  more...
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Medical Care

Rickettsialpox is a self-limited disease; however, antibiotics hasten defervescence and provide relief of other systemic symptoms. A presumptive diagnosis of rickettsialpox can be made based on high clinical suspicion in the correct geographic context, and empiric antimicrobial therapy can be appropriately prescribed. The treatment of choice is doxycycline 100 mg administered orally twice daily until the patient has clinically recovered for approximately 48 hours. Usually, 5-7 days is sufficient. Supportive and symptomatic therapy may also be provided.



If antibiotics cause no response within 48 hours, seek an alternate diagnosis.