Human Parainfluenza Viruses (HPIV) and Other Parainfluenza Viruses Differential Diagnoses

1. Kelly J. Henrickson. Parainfluenza Viruses. Clinical Microbiology Reviews. April 2003. 16:242-264. [QxMD MEDLINE Link]. [Full Text].

2. Fry AM, Curns AT, Harbour K, et al. Seasonal trends of human parainfluenza viral infections: United States, 1990-2004. Clin Infect Dis. 2006 Oct 15. 43(8):1016-22. [QxMD MEDLINE Link].

3. Senchi K, Matsunaga S, Hasegawa H, Kimura H, Ryo A. Development of oligomannose-coated liposome-based nasal vaccine against human parainfluenza virus type 3. Front Microbiol. 2013. 4:346. [QxMD MEDLINE Link].

4. Liu WK, Liu Q, Chen DH, Liang HX, Chen XK, Huang WB. Epidemiology and clinical presentation of the four human parainfluenza virus types. BMC Infect Dis. 2013. 13:28. [QxMD MEDLINE Link].

5. Chambers R, Takimoto T. Parainfluenza Viruses. eLS. 2011.

6. Burke CW, Bridges O, Brown S, Rahija R, Russell CJ. Mode of parainfluenza virus transmission determines the dynamics of primary infection and protection from reinfection. PLoS Pathog. 2013 Nov. 9(11):e1003786. [QxMD MEDLINE Link].

7. Schomacker H, Schaap-Nutt A, Collins PL, Schmidt AC. Pathogenesis of acute respiratory illness caused by human parainfluenza viruses. Curr Opin Virol. 2012 Jun. 2 (3):294-9. [QxMD MEDLINE Link].

8. Karron RA and Collins PL. Knipe DM; Howley PM; Griffin DE; Martin MA; Lamb RA; Roizman B; Strauss SE. 5th. Field’s Virology. Philadelphia: Lippincott Williams & Wilkins; 2007. 1497-1527.

9. Henrickson KJ. Parainfluenza viruses. Clin Microbiol Rev. 2003 Apr. 16(2):242-64. [QxMD MEDLINE Link]. [Full Text].

10. Lau SK, To WK, Tse PW, et al. Human parainfluenza virus 4 outbreak and the role of diagnostic tests. J Clin Microbiol. 2005 Sep. 43(9):4515-21. [QxMD MEDLINE Link].

11. Abedi GR, Prill MM, Langley GE, Wikswo ME, Weinberg GA, Curns AT, et al. Estimates of Parainfluenza Virus-Associated Hospitalizations and Cost Among Children Aged Less Than 5 Years in the United States, 1998-2010. J Pediatric Infect Dis Soc. 2016 Mar. 5 (1):7-13. [QxMD MEDLINE Link].

12. Schnepf N, Resche-Rigon M, Chaillon A, Scemla A, Gras G, Semoun O. PLoS One. Aug 17 2011;6(8):e23514. High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France.

13. Zhao H, Harris RJ, Ellis J, Donati M, Pebody RG. Epidemiology of parainfluenza infection in England and Wales, 1998-2013: any evidence of change?. Epidemiol Infect. 2017 Apr. 145 (6):1210-1220. [QxMD MEDLINE Link].

14. Horton KC, Dueger EL, Kandeel A, Abdallat M, El-Kholy A, Al-Awaidy S, et al. Viral etiology, seasonality and severity of hospitalized patients with severe acute respiratory infections in the Eastern Mediterranean Region, 2007-2014. PLoS One. 2017. 12 (7):e0180954. [QxMD MEDLINE Link].

15. Esposito S, Daleno C, Prunotto G, Scala A, Tagliabue C, Borzani I, et al. Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. Influenza Other Respir Viruses. 2013 Jan. 7 (1):18-26. [QxMD MEDLINE Link].

16. Ben-Shimol S, Landau D, Zilber S, Greenberg D. Parainfluenza virus type 3 outbreak in a neonatal nursery. Clin Pediatr (Phila). 2013 Sep. 52(9):866-70. [QxMD MEDLINE Link].

17. [Guideline] Massachusetts Department of Public Health; 2008 Jan 31. p. 42-9. Standard precautions in hospitals. In: Betsy Lehman Center for Patient Safety and Medical Error Reduction, JSI Research and Training Institute, Inc. Prevention and control of healthcare-associated infections in Mass. Part 1: final recommendations of the Expert Panel. [Full Text].

18. Seo S, Xie H, Campbell AP, Kuypers JM, Leisenring WM, Englund JA. Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplant: viral detection in the lung predicts outcome. Clin Infect Dis. 2014 May. 58(10):1357-68. [QxMD MEDLINE Link].

19. Weinberg GA, Hall CB, Iwane MK, Poehling KA, Edwards KM, Griffin MR, et al. Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization. J Pediatr. May 2009;154(5):694-9.:

20. American Academy of Pediatrics. Red Book: 2009 Report of the Committee on Infectious Diseases. 28th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2009. Undefined.

21. López Pérez G, Morfín Maciel BM, Navarrete N, Aguirre A. Identification of influenza, parainfluenza, adenovirus and respiratory syncytial virus during rhinopharyngitis in a group of Mexican children with asthma and wheezing. Rev Alerg Mex. 2009 May-Jun. 56(3):86-91. [QxMD MEDLINE Link].

22. Johnson D. Croup. Clin Evid (Online). March 10 2009;pii:0321. Undefined.

23. Stankova J, Carret AS, Moore D, McCusker C, Mitchell D, Davis M, et al. Long-term therapy with aerosolized ribavirin for parainfluenza 3 virus respiratory tract infection in an infant with severe combined immunodeficiency. Pediatr Transplant. 2007 Mar. 11(2):209-13. [QxMD MEDLINE Link].

24. Juozapaitis M, Zvirbliene A, Kucinskaite I, Sezaite I, Slibinskas R, Coiras M, et al. Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiae. Virus Res. May 2008;133(2):178-86.:

25. Ma GF, Miettinen S, Porola P, Hedman K, Salo J, Konttinen YT. Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. BMC Microbiol. 2009;9:55. Undefined.

26. Kuypers J, Campbell AP, Cent A, Corey L, Boeckh M. Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients. Transpl Infect Dis. Aug 2009;11(4):298-303. Undefined.

27. Yoo SJ, Kuak EY, Shin BM. Detection of 12 respiratory viruses with two-set multiplex reverse transcriptase-PCR assay using a dual priming oligonucleotide system. Korean J Lab Med. Dec 2007;27(6):420-7. Undefined.

28. Brittain-Long R, Andersson LM, Olofsson S, Lindh M, Westin J. Seasonal variations of 15 respiratory agents illustrated by the application of a multiplex polymerase chain reaction assay. Scand J Infect Dis. Jan 2012;44(1):9-17. Undefined.

29. van de Pol AC, Wolfs TF, Jansen NJ, van Loon AM, Rossen JW. Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection. Crit Care. 2006. 10 (2):R61. [QxMD MEDLINE Link].

30. Wu KW, Wang SM, Shen CF, Ho TS, Wang JR, Liu CC. Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan. J Microbiol Immunol Infect. 2017 Jun 22. [QxMD MEDLINE Link].

31. Ko DH, Kim HS, Hyun J, Kim HS, Kim JS, Park KU, et al. Comparison of the Luminex xTAG Respiratory Viral Panel Fast v2 Assay With Anyplex II RV16 Detection Kit and AdvanSure RV Real-Time RT-PCR Assay for the Detection of Respiratory Viruses. Ann Lab Med. 2017 Sep. 37 (5):408-414. [QxMD MEDLINE Link].

32. Schmidt AC, Schaap-Nutt A, Bartlett EJ, Schomacker H, Boonyaratanakornkit J, Karron RA, et al. Progress in the development of human parainfluenza virus vaccines. Expert Rev Respir Med. 2011 Aug. 5 (4):515-26. [QxMD MEDLINE Link].

33. Watanabe M, Mishin VP, Brown SA, Russell CJ, Boyd K, Babu YS, et al. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob Agents Chemother. Sep 2009;53(9):3942-51.:

34. Gomez M, Mufson MA, Dubovsky F, Knightly C, Zeng W, Losonsky G. Phase-I study medi-534, of a live, attenuated intranasal vaccine against respiratory syncytial virus and parainfluenza-3 virus in seropositive children. Pediatr Infect Dis J. Jul 2009;28(7):655-8.:

35. Skiadopoulos MH, Tao T, Surman SR, Collins PL, Murphy BR. Generation of a parainfluenza virus type 1 vaccine candidate by replacing the HN and F glycoproteins of the live-attenuated PIV3 cp45 vaccine virus with their PIV1 counterparts. Vaccine. Oct 199... Undefined.

36. Schmidt AC, Schaap-Nutt A, Bartlett EJ, Schomacker H, Boonyaratanakornkit J, Karron RA, et al. Progress in the development of human parainfluenza virus vaccines. Expert Rev Respir Med. Aug 2011;5(4):515-26.:

37. Karron RA, Belshe RB, Wright PF, Thumar B, Burns B, Newman F, et al. A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in young infants. Pediatr Infect Dis J. 2003 May. 22(5):394-405. [QxMD MEDLINE Link].

Subhash Chandra Parija, MD, MBBS, PhD, DSc, FRCPath Director, Jawaharlal Institute of Postgraduate Medical Education and Research, India

Subhash Chandra Parija, MD, MBBS, PhD, DSc, FRCPath is a member of the following medical societies: Indian Academy of Tropical Parasitology, Indian Association of Biomedical Scientists, Indian Association of Medical Microbiologists, Indian Association of Pathologists and Microbiologists, Indian Medical Association, Indian Society for Parasitology, National Academy of Medical Sciences (India), Royal College of Pathologists

Disclosure: Nothing to disclose.

Thomas J Marrie, MD Dean of Faculty of Medicine, Dalhousie University Faculty of Medicine, Canada

Thomas J Marrie, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society for Microbiology, Association of Medical Microbiology and Infectious Disease Canada, Royal College of Physicians and Surgeons of Canada

Disclosure: Nothing to disclose.

Michael Stuart Bronze, MD David Ross Boyd Professor and Chairman, Department of Medicine, Stewart G Wolf Endowed Chair in Internal Medicine, Department of Medicine, University of Oklahoma Health Science Center; Master of the American College of Physicians; Fellow, Infectious Diseases Society of America; Fellow of the Royal College of Physicians, London

Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical Investigation

Disclosure: Nothing to disclose.

Jeffrey D Band, MD Professor of Medicine, Oakland University William Beaumont School of Medicine; Director, Division of Infectious Diseases and International Medicine, Corporate Epidemiologist, William Beaumont Hospital; Clinical Professor of Medicine, Wayne State University School of Medicine

Disclosure: Nothing to disclose.

Richard B Brown, MD, FACP Chief, Division of Infectious Diseases, Baystate Medical Center; Professor, Department of Internal Medicine, Tufts University School of Medicine

Richard B Brown, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Chest Physicians, American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, and Massachusetts Medical Society

Disclosure: Nothing to disclose.

Joseph Domachowske, MD Professor of Pediatrics, Microbiology and Immunology, Department of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University

Joseph Domachowske, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Ashir Kumar, MD, MBBS, FAAP Professor Emeritus, Department of Pediatrics and Human Development, Michigan State University College of Human Medicine

Ashir Kumar, MD, MBBS, FAAP is a member of the following medical societies: American Association of Physicians of Indian Origin and Infectious Diseases Society of America

Disclosure: Nothing to disclose.

Russell W Steele, MD Head, Division of Pediatric Infectious Diseases, Ochsner Children's Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine

Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Roy M Vega, MD Assistant Professor of Pediatrics, Albert Einstein College of Medicine; Director, Pediatric Emergency Services, Department of Emergency Medicine, Bronx Lebanon Hospital Center, Bronx, NY

Roy M Vega, MD is a member of the following medical societies: American Academy of Pediatrics

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

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