Castleman Disease Questions & Answers

Updated: Nov 24, 2021
  • Author: Geneva E Guarin, MD, MBA; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is Castleman disease (CD)?

What are the subtypes of Castleman disease (CD)?

How is Castleman disease (CD) diagnosed?

How is Castleman disease (CD) treated?

What is the Castleman Disease Collaborative Network?

What is the pathophysiology of Castleman disease (CD)?

What are the microscopic features of Castleman disease (CD)?

What causes Castleman disease (CD)?

What are the subgroups of human herpesvirus-8–associated multicentric Castleman disease (HHV-8-associated MCD)?

What are the risk factors for developing HHV-8–associated multicentric Castleman disease (HHV-8-associated MCD)?

How common is Castleman disease (CD) in the US?

What are the sex- and age-related demographics of Castleman disease (CD)?

What is the prognosis of Castleman disease (CD)?

What are the patient education resources for Castleman disease (CD)?

Presentation

What is the clinical presentation of human herpesvirus 8–associated multicentric Castleman disease (HHV-8-associated MCD)?

What is the clinical presentation of unicentric Castleman disease (UCD)?

What are the signs and symptoms of idiopathic multicentric Castleman disease (iMCD)?

What are the clinical features of idiopathic multicentric Castleman disease (iMCD)?

Which conditions co-occur with idiopathic multicentric Castleman disease (iMCD)?

DDX

What is included in the differential diagnosis of human herpesvirus 8–associated multicentric Castleman disease (HHV-8–associated MCD)?

Which disorders can mimic human herpesvirus 8–negative/idiopathic multicentric Castleman disease (HHV-8-associated iMCD)?

What is included in the differential diagnosis of unicentric Castleman disease (UCD)?

What is included in the differential diagnosis of the hyaline vascular histopathological subtype of unicentric Castleman disease (UCD)?

What is included in the differential diagnosis of the plasma cell histopathological subtype of unicentric Castleman disease (UCD)?

Workup

What are the histopathological lymph node features of the unicentric Castleman disease (UCD) subtypes?

What are the approach considerations in the workup of unicentric Castleman disease (UCD)?

How is human herpesvirus 8–associated multicentric Castleman disease (HHV-8-associated MCD) diagnosed?

What are the diagnostic criteria for idiopathic Castleman disease (iCD)?

Which imaging studies are indicated in the workup of Castleman disease (CD)?

Which lab studies are indicated in the workup of Castleman disease (CD)?

What is the role of lymph node biopsy in the workup of Castleman disease (CD)?

Treatment

How is human herpesvirus 8 (HHV-8)–associated multicentric Castleman disease (MCD) treated?

What is the treatment for Castleman disease (CD)?

How is unicentric Castleman disease (UCD) treated?

How is human herpesvirus 8 (HHV-8)–negative Castleman disease (MCD) treated?

What surgical treatment is indicated in unicentric Castleman disease (UCD)?

What long-term monitoring is indicated in Castleman disease (CD)?

Medications

Which medications are indicated in the treatment of Castleman disease (CD)?

Which medications in the drug class Immunomodulators are used in the treatment of Castleman Disease?