Female Orgasmic Disorder Medication

Updated: Jul 24, 2018
  • Author: Adrian Preda, MD; Chief Editor: David Bienenfeld, MD  more...
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Medication Summary

The goals of pharmacotherapy are to reduce sex-associated anxiety and cognitive distortions that could interfere with libido.


Antidepressants, Other

Class Summary

The mixed serotonergic and noradrenergic drugs have effects on serotonin, norepinephrine, and, in some cases, dopamine and even on nicotinic acetylcholine systems. Because of the empirical nature of psychopharmacology, they may be used as first-line drugs or as alternative agents when other antidepressants cause adverse effects.

Bupropion (Wellbutrin, Fortivo XL, Aplenzin)

Bupropion is used as an alternative in antidepressant-induced inhibited male orgasm. It inhibits neuronal dopamine reuptake, but it is also a weak blocker of serotonin and norepinephrine reuptake. A low incidence of sexual dysfunctions occurs with this medication.


Antiparkinson Agents, Dopamine Agonists

Class Summary

These agents selectively act on different subtypes of dopamine receptors throughout the brain. The mechanergic agonists’ action is independent of the functional capacities of the striatonigral neurons.

Apomorphine (Apokyn)

Apomorphine acts in D2 brain receptors known to be involved in sexual function.