Chancroid Differential Diagnoses

Updated: Mar 23, 2022
  • Author: Joseph Adrian L Buensalido, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Diagnostic Considerations

Herpes simplex and syphilitic chancre are the most common causes of genital ulcers. The documented decline in chancroid prevalence should be interpreted with caution owing to difficulty in isolation of H ducreyi. It should still be considered, especially in patients who have travelled to or are from endemic areas. Given this limitation, the Centers for Disease Control and Prevention (CDC) has proposed a case definition for probable chancroid, once all of the following criteria are met [43] :

  • One or more painful genital ulcers
  • Presentation and physical appearance of ulcers and lymphadenopathy typical of chancroid
  • No evidence of Treponema pallidum infection on darkfield examination of ulcer exudate and/or serological evidence at least 7 days after ulcer onset
  • Polymerase chain reaction (PCR) or culture of ulcer exudate negative for herpes simplex virus (HSV)

Other infectious causes include lymphogranuloma venereum and granuloma inguinale. Noninfectious causes include psoriasis, trauma, Behçet syndrome, and fixed drug eruptions. [44]

Differential Diagnoses