Kikuchi Disease Follow-up

Updated: Nov 13, 2020
  • Author: John Boone, MD; Chief Editor: Sara J Grethlein, MD, MBA, FACP  more...
  • Print


Kikuchi disease is generally a self-limited disease with a favorable prognosis. Lymphadenopathy usually resolves within 1-6 months after onset, although it may persist longer. About 3% of patients experience recurrence.

Four deaths have been reported. Three patients died during the acute phase of generalized Kikuchi disease. One patient died from cardiac failure; another from the effects of hepatic and pulmonary involvement; and a third, from an acute lupuslike syndrome. A fourth patient, who had concurrent systemic lupus erythematosus, died from complications of hemophagocytic syndrome and severe infection . [2]