Light-Chain Deposition Disease Clinical Presentation

Updated: Sep 26, 2019
  • Author: Swapna Boppana, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Patients are found to have light-chain deposition disease (LCDD) when they are evaluated for proteinuria or nephrotic syndrome by renal biopsy. The common symptoms and signs are related to associated organ involvement and may manifest as renal failure, congestive heart failure, and/or liver failure. Most patients present with advanced disease, owing to a delay in the diagnosis.



Light-chain deposition disease (LCDD) patients may present with end organ damage, which chiefly manifests as hypertension, peripheral edema, neuropathy, or congestive heart failure. Approximately 50% of patients with LCDD present with nephrotic syndrome. However, in a quarter of patients, the proteinuria is less than 1 g/day as a result of tubulointerstitial involvement.