Overview
What are the diagnostic criteria for chronic eosinophilic leukemia?
What is hypereosinophilic syndrome?
Which conditions are included in the differential diagnoses of hypereosinophilic syndrome?
What causes secondary eosinophilia?
What causes of clonal eosinophilia?
What causes of idiopathic eosinophilia?
What is the pathophysiology of hypereosinophilic syndrome?
What is the role of chemoattractants in the pathophysiology of hypereosinophilic syndrome?
What are the mechanisms for the pathogenesis of hypereosinophilic syndrome?
What is the prevalence of hypereosinophilic syndrome?
What are the mortality rates of hypereosinophilic syndrome?
Which patient groups have the highest prevalence of hypereosinophilic syndrome?
Presentation
Which clinical history findings are characteristic of hypereosinophilic syndrome?
What are the neurologic symptoms of hypereosinophilic syndrome?
What are the respiratory symptoms of hypereosinophilic syndrome?
What are the rheumatologic symptoms of hypereosinophilic syndrome?
What are the dermatologic symptoms of hypereosinophilic syndrome?
What are the GI symptoms of hypereosinophilic syndrome?
What are the constitutional signs and symptoms of hypereosinophilic syndrome?
Which cardiac findings are characteristic of hypereosinophilic syndrome?
Which hematologic findings are characteristic hypereosinophilic syndrome?
Which neurologic findings are characteristic of hypereosinophilic syndrome?
Which pulmonary findings are characteristic of hypereosinophilic syndrome?
Which rheumatologic findings are characteristic of hypereosinophilic syndrome?
Which dermatologic findings are characteristic of hypereosinophilic syndrome?
Which cutaneous findings suggest hypereosinophilic syndrome?
Which GI findings are characteristic of hypereosinophilic syndrome?
DDX
Which conditions should be included in the differential diagnoses of hypereosinophilic syndrome?
What should be the focus of history in the evaluation of hypereosinophilic syndrome?
What are the differential diagnoses for Hypereosinophilic Syndrome?
Workup
How is hypereosinophilic syndrome diagnosed?
What is the role of bone marrow biopsy in the diagnosis of hypereosinophilic syndrome?
When is human leukocyte antigen (HLA) typing indicated in the workup of hypereosinophilic syndrome?
Which studies are helpful in the workup of hypereosinophilic syndrome?
Which studies are performed in the initial evaluation of suspected hypereosinophilic syndrome?
What is the role of imaging studies in the workup of hypereosinophilic syndrome?
Which histologic findings are characteristic of hypereosinophilic syndrome?
Which blood study findings are characteristic of hypereosinophilic syndrome?
What is the role of biopsy in the evaluation of hypereosinophilic syndrome?
Treatment
How is hypereosinophilic syndrome treated?
How is refractory hypereosinophilic syndrome treated?
How are thromboembolic complications treated in hypereosinophilic syndrome?
How is hyperleukocytosis treated in hypereosinophilic syndrome?
When is consultation with a hematologist indicated for the treatment of hypereosinophilic syndrome?
How is vascular disease treated in hypereosinophilic syndrome?
When is splenectomy indicated in the treatment of hypereosinophilic syndrome?
What is the role of glucocorticoids in the treatment of hypereosinophilic syndrome?
What is the role of imatinib in the treatment of hypereosinophilic syndrome?
What are the second-line medications used in the treatment of hypereosinophilic syndrome?
Medications
What are goals of drug treatment for hypereosinophilic syndrome?
Follow-up
What are the possible complications of hypereosinophilic syndrome?
What is the prognosis of hypereosinophilic syndrome?
What are favorable prognostic factors for hypereosinophilic syndrome?
What is included in the long-term monitoring of patients with hypereosinophilic syndrome?
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Indurated edematous plaques of hypereosinophilic syndrome on a patient's legs.
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Erythroderma in a patient with hypereosinophilic syndrome.