Folate Deficiency Questions & Answers

Updated: Nov 03, 2020
  • Author: Katherine Coffey-Vega, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Questions & Answers

Overview

What is folate deficiency?

Which patient groups are at the highest risk for folate deficiency?

What are the clinical implications of folate deficiency?

What is the pathophysiology of folate deficiency?

What is the US prevalence of folate deficiency?

What is the global prevalence of folate deficiency?

What are the hematologic manifestations of folate deficiency?

What are the cardiac complications of folate deficiency?

What are the pregnancy complications of folate deficiency?

What is the role of folate deficiency in carcinogenesis?

How does folate deficiency affect cognitive functioning?

Which patient populations are at increased risk for folate deficiency?

Presentation

Which clinical history findings are characteristic of folate deficiency?

Which physical findings are characteristic of folate deficiency?

What causes folate deficiency?

What is the role of nutrition in the etiology of folate deficiency?

What causes impaired absorption in folate deficiency?

What is the role of impaired metabolism in the etiology of folate deficiency?

What causes an increase in folate requirement?

What causes increased excretion in folate deficiency?

What causes increased destruction of folic acid in folate deficiency?

DDX

What are the differential diagnoses for Folate Deficiency?

Workup

What is the role of lab testing in the workup of folate deficiency?

What is the role of biopsy in the workup of folate deficiency?

Treatment

How is folate deficiency treated?

Medications

What is the role of medications in the treatment of folic acid deficiency?

Which medications in the drug class Vitamins are used in the treatment of Folate Deficiency?

Follow-up

How is folate deficiency prevented?

What is included in patient education about folate deficiency?

What are the adverse effects of untreated folate deficiency on pregnancy outcomes?

What causes irreversible neuropathy in patients with folate deficiency?

How is cognition improved in patients with folate deficiency?