Bone Marrow Failure Differential Diagnoses

Updated: Dec 11, 2019
  • Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Koyamangalath Krishnan, MD, FRCP, FACP  more...
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DDx

Diagnostic Considerations

Conditions to consider in the differential diagnosis of bone marrow failure include the following:

  • Myelodysplastic syndromes

  • Large granular lymphocytic leukemia.

  • Immune pancytopenias in connective tissue disorders  (eg, refractory anemia in systemic lupus erythematosus)

An evaluation for IBMFS should be considered for all patients presenting with AA, MDS, acute myeloid leukemia (AML), and chronic unexplained cytopenias. This assessment is likely most critical for patients who are younger than age 40 years at presentation, but diagnoses of some patients with IBMFSs have been reported into their 50s or older. Patients with excess hematologic or other toxicities during treatment of an early-onset solid tumor characteristic of the IBMFSs also warrant an evaluation. [5]

Differential Diagnoses