Intestinal Motility Disorders Questions & Answers

1. Di Lorenzo C, Youssef NN. Diagnosis and management of intestinal motility disorders. Semin Pediatr Surg. 2010 Feb. 19(1):50-8. [QxMD MEDLINE Link].

2. Keller J, Layer P. Intestinal and anorectal motility and functional disorders. Best Pract Res Clin Gastroenterol. 2009. 23(3):407-23. [QxMD MEDLINE Link].

3. Venkatasubramani N, Sood MR. Motility disorders of the gastrointestinal tract. Indian J Pediatr. 2006 Oct. 73(10):927-30. [QxMD MEDLINE Link].

4. Ouyang A, Locke GR 3rd. Overview of neurogastroenterology-gastrointestinal motility and functional GI disorders: classification, prevalence, and epidemiology. Gastroenterol Clin North Am. 2007 Sep. 36(3):485-98, vii. [QxMD MEDLINE Link].

5. Rao SS. Constipation: evaluation and treatment of colonic and anorectal motility disorders. Gastroenterol Clin North Am. 2007 Sep. 36(3):687-711, x. [QxMD MEDLINE Link].

6. Wouters MM, Vicario M, Santos J. The role of mast cells in functional GI disorders. Gut. 2016 Jan. 65(1):155-68. [QxMD MEDLINE Link].

7. Knowles CH, Martin JE. Slow transit constipation: a model of human gut dysmotility. Review of possible aetiologies. Neurogastroenterol Motil. 2000 Apr. 12(2):181-96. [QxMD MEDLINE Link].

8. Bestetti A, Capozza A, Lacerenza M, Manfredi L, Mancini F. Delayed gastric emptying in advanced Parkinson disease: correlation with therapeutic doses. Clin Nucl Med. 2017 Feb. 42(2):83-7. [QxMD MEDLINE Link].

9. den Braber-Ymker M, Lammens M, van Putten MJ, Nagtegaal ID. The enteric nervous system and the musculature of the colon are altered in patients with spina bifida and spinal cord injury. Virchows Arch. 2017 Feb. 470(2):175-84. [QxMD MEDLINE Link]. [Full Text].

10. Rozman RW Jr, Achkar E. Features distinguishing secondary achalasia from primary achalasia. Am J Gastroenterol. 1990 Oct. 85(10):1327-30. [QxMD MEDLINE Link].

11. Labenz J, Jaspersen D, Kulig M, et al. Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. Am J Gastroenterol. 2004 Sep. 99(9):1652-6. [QxMD MEDLINE Link].

12. Hyett B, Martinez FJ, Gill BM, et al. Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. Gastroenterology. 2009 Aug. 137(2):445-52. [QxMD MEDLINE Link].

13. Shafik A, Shafik AA, El-Sibai O, Shafik IA. Interstitial cells of cajal in patients with constipation due to total colonic inertia. J Invest Surg. 2006 May-Jun. 19(3):147-53. [QxMD MEDLINE Link].

14. Chudzinski AP, Thompson EV, Ayscue JM. Acute colonic pseudoobstruction. Clin Colon Rectal Surg. 2015 Jun. 28(2):112-7. [QxMD MEDLINE Link]. [Full Text].

15. Amiel J, Sproat-Emison E, Garcia-Barcelo M, et al, for the Hirschsprung Disease Consortium. Hirschsprung disease, associated syndromes and genetics: a review. J Med Genet. 2008 Jan. 45(1):1-14. [QxMD MEDLINE Link]. [Full Text].

16. Amiot A, Tchikviladze M, Joly F, et al. Frequency of mitochondrial defects in patients with chronic intestinal pseudo-obstruction. Gastroenterology. 2009 Jul. 137(1):101-9. [QxMD MEDLINE Link].

17. Li B, Wang JR, Ma YL. Bowel sounds and monitoring gastrointestinal motility in critically ill patients. Clin Nurse Spec. 2012 Jan. 26(1):29-34. [QxMD MEDLINE Link].

18. Remes-Troche JM, Rao SS. Diagnostic testing in patients with chronic constipation. Curr Gastroenterol Rep. 2006 Oct. 8(5):416-24. [QxMD MEDLINE Link].

19. Maqbool S, Parkman HP, Friedenberg FK. Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit. Dig Dis Sci. 2009 Oct. 54(10):2167-74. [QxMD MEDLINE Link].

20. [Guideline] American College of Radiology (ACR), the Society of Nuclear Medicine (SNM), and the Society for Pediatric Radiology (SPR). ACR–SNM–SPR Practice parameter for the performance of gastrointestinal scintigraphy. Res. 29 – 2010, Amended 2014 (Res. 39). ACR American College of Radiology. Available at http://www.acr.org/Quality-Safety/Standards-Guidelines/Practice-Guidelines-by-Modality/Nuclear-Medicine. Accessed: October 29, 2014.

21. [Guideline] ACR–ACNM–SNMMI–SPR Practice parameter for the performance of gastrointestinal tract, hepatic, and splenic scintigraphy. Resolution 16. Rev 2020. [Full Text].

22. Alyami J, Spiller RC, Marciani L. Magnetic resonance imaging to evaluate gastrointestinal function. Neurogastroenterol Motil. 2015 Dec. 27(12):1687-92. [QxMD MEDLINE Link].

23. Burns AJ. Disorders of interstitial cells of Cajal. J Pediatr Gastroenterol Nutr. 2007 Dec. 45(Suppl 2):S103-6. [QxMD MEDLINE Link].

24. He CL, Burgart L, Wang L, Pemberton J, Young-Fadok T, Szurszewski J, et al. Decreased interstitial cell of cajal volume in patients with slow-transit constipation. Gastroenterology. 2000 Jan. 118(1):14-21. [QxMD MEDLINE Link].

25. Pardi DS, Miller SM, Miller DL, et al. Paraneoplastic dysmotility: loss of interstitial cells of Cajal. Am J Gastroenterol. 2002 Jul. 97(7):1828-33. [QxMD MEDLINE Link].

26. Sanders KM. Interstitial cells of Cajal at the clinical and scientific interface. J Physiol. 2006 Nov 1. 576(Pt 3):683-7. [QxMD MEDLINE Link].

27. Vanuytsel T, Tack JF, Boeckxstaens GE. Treatment of abdominal pain in irritable bowel syndrome. J Gastroenterol. 2014 Aug. 49(8):1193-205. [QxMD MEDLINE Link].

28. Hotta R, Stamp LA, Foong JP, et al. Transplanted progenitors generate functional enteric neurons in the postnatal colon. J Clin Invest. 2013 Mar 1. 123(3):1182-91. [QxMD MEDLINE Link]. [Full Text].

29. Cleveland Clinical Foundation, Center for Gastrointestinal Motility Disorders. Intestinal motility disorders. Cleveland Clinic. Available at http://www.ccf.org/gastro/motility/default.htm. 1999;

30. Fu A. Neostigmine: an alternative treatment for constipation. Dynamics. 2005. 16(1):13-5. [QxMD MEDLINE Link].

31. Karamanolis G, Tack J. Promotility medications--now and in the future. Dig Dis. 2006. 24(3-4):297-307. [QxMD MEDLINE Link].

32. Sarna SK. Molecular, functional, and pharmacological targets for the development of gut promotility drugs. Am J Physiol Gastrointest Liver Physiol. 2006 Oct. 291(4):G545-55. [QxMD MEDLINE Link].

33. Quigley EM. Prucalopride: safety, efficacy and potential applications. Therap Adv Gastroenterol. 2012 Jan. 5(1):23-30. [QxMD MEDLINE Link]. [Full Text].

34. Malagelada C, Nieto A, Mendez S, Accarino A, Santos J, Malagelada JR, et al. Effect of prucalopride on intestinal gas tolerance in patients with functional bowel disorders and constipation. J Gastroenterol Hepatol. 2017 Aug. 32(8):1457-62. [QxMD MEDLINE Link].

35. Bassotti G, Gambaccini D, Bellini M. Prucalopride succinate for the treatment of constipation: an update. Expert Rev Gastroenterol Hepatol. 2016. 10(3):291-300. [QxMD MEDLINE Link].

36. Saunders MD, Kimmey MB. Systematic review: acute colonic pseudo-obstruction. Aliment Pharmacol Ther. 2005. 22(10):917. [QxMD MEDLINE Link]. [Full Text].

37. Mellgren A, Matzel KE, Pollack J, et al, for the Nasha Dx Study Group. Long-term efficacy of NASHA Dx injection therapy for treatment of fecal incontinence. Neurogastroenterol Motil. 2014 Aug. 26(8):1087-94. [QxMD MEDLINE Link]. [Full Text].

38. Mazzone A, Farrugia G. Evolving concepts in the cellular control of gastrointestinal motility: neurogastroenterology and enteric sciences. Gastroenterol Clin North Am. 2007 Sep. 36(3):499-513, vii. [QxMD MEDLINE Link].

39. Sigurdsson L, Reyes J, Kocoshis SA, et al. Intestinal transplantation in children with chronic intestinal pseudo-obstruction. Gut. 1999 Oct. 45(4):570-4. [QxMD MEDLINE Link]. [Full Text].

40. Millar AJ, Gupte G, Sharif K. Intestinal transplantation for motility disorders. Semin Pediatr Surg. 2009 Nov. 18(4):258-62. [QxMD MEDLINE Link].

41. [Guideline] Tack J, Vanuytsel T, Serra J, et al, for the ESNM Consensus Group, the Leuven Consensus Group, et al. European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic. Neurogastroenterol Motil. 2020 Jul. 32 (7):e13930. [QxMD MEDLINE Link]. [Full Text].

42. [Guideline] Keller J, Bassotti G, Clarke J, et al, for the International Working Group for Disorders of Gastrointestinal Motility and Function. Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders. Nat Rev Gastroenterol Hepatol. 2018 May. 15 (5):291-308. [QxMD MEDLINE Link]. [Full Text].

43. Parthasarathy G, Ravi K, Camilleri M, et al. Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders. Neurogastroenterol Motil. 2015 Dec. 27(12):1736-46. [QxMD MEDLINE Link]. [Full Text].

44. De Giorgio R, Cogliandro RF, Barbara G, Corinaldesi R, Stanghellini V. Chronic intestinal pseudo-obstruction: clinical features, diagnosis, and therapy. Gastroenterol Clin North Am. 2011 Dec. 40(4):787-807. [QxMD MEDLINE Link].

45. Rudolph CD, Hyman PE, Altschuler SM, et al. Diagnosis and treatment of chronic intestinal pseudo-obstruction in children: report of consensus workshop. J Pediatr Gastroenterol Nutr. 1997 Jan. 24(1):102-12. [QxMD MEDLINE Link].

46. Menys A, Butt S, Emmanuel A, et al. Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls. Neurogastroenterol Motil. 2016 Mar. 28(3):376-83. [QxMD MEDLINE Link].

47. Goyal H, Singla U, Gupta U, May E. Role of cannabis in digestive disorders. Eur J Gastroenterol Hepatol. 2017 Feb. 29(2):135-43. [QxMD MEDLINE Link].

48. Vasant DH, Pironi L, Barbara G, et al. An international survey on clinicians' perspectives on the diagnosis and management of chronic intestinal pseudo-obstruction and enteric dysmotility. Neurogastroenterol Motil. 2020 Jul 22. e13937. [QxMD MEDLINE Link]. [Full Text].

49. Ghisa M, Barberio B, Lorenzon G, Zingone F, Savarino E. Reorganization of the functional gastrointestinal disorders unit during the SARS-CoV-2 outbreak - Practical Recommendations. Dig Liver Dis. 2020 Jul 10. [QxMD MEDLINE Link]. [Full Text].

Mia L Manabat, DO Gastroenterologist, Aurora Health Care

Mia L Manabat, DO is a member of the following medical societies: American College of Osteopathic Internists, American Osteopathic Association

Disclosure: Nothing to disclose.

Michael H Piper, MD Clinical Assistant Professor, Department of Internal Medicine, Division of Gastroenterology, Wayne State University School of Medicine; Consulting Staff, Digestive Health Associates, PLC

Michael H Piper, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Gastroenterology, American College of Physicians, Michigan State Medical Society

Disclosure: Nothing to disclose.

Burt Cagir, MD, FACS Associate Regional Dean and Professor of Surgery, Geisinger Commonwealth School of Medicine; Director, General Surgery Residency Program, Executive Director, Donald Guthrie Foundation for Research and Education, Guthrie Robert Packer Hospital; Medical Director, Guthrie/RPH Skills and Simulation Lab; Associate in Surgery, Guthrie Robert Packer Hospital and Corning Hospital

Burt Cagir, MD, FACS is a member of the following medical societies: American College of Surgeons, Association of Program Directors in Surgery, Society for Surgery of the Alimentary Tract

Disclosure: Nothing to disclose.

Vivek V Gumaste, MD Associate Professor of Medicine, Mount Sinai School of Medicine of New York University; Adjunct Clinical Assistant, Mount Sinai Hospital; Director, Division of Gastroenterology, City Hospital Center at Elmhurst; Program Director of GI Fellowship (Independent Program); Regional Director of Gastroenterology, Queens Health Network

Vivek V Gumaste, MD is a member of the following medical societies: American College of Gastroenterology, American Gastroenterological Association

Disclosure: Nothing to disclose.

Nafisa K Kuwajerwala, MD Staff Surgeon, Breast Care Center, William Beaumont Hospital

Nafisa K Kuwajerwala, MD is a member of the following medical societies: American College of Surgeons, American Society of Breast Surgeons, American Society of Breast Disease

Disclosure: Nothing to disclose.

Luigi Santacroce, MD Assistant Professor, Medical School, State University at Bari, Italy

Disclosure: Nothing to disclose.

Venkata Subramanian Kanthimathinathan, MD Fellow in Bariatric/Advanced Laparoscopic Surgery, University of Missouri Healthcare

Disclosure: Nothing to disclose.

Silvia Gagliardi, MD Consulting Staff, Department of Surgery, Medical Center Vita, Italy

Disclosure: Nothing to disclose.

Douglas M Heuman, MD, FACP, FACG, AGAF Chief of GI, Hepatology, and Nutrition at North Shore University Hospital/Long Island Jewish Medical Center; Professor, Department of Medicine, Hofstra North Shore-LIJ School of Medicine

Douglas M Heuman, MD, FACP, FACG, AGAF is a member of the following medical societies: American Association for the Study of Liver Diseases, American College of Physicians, and American Gastroenterological Association

Disclosure: Novartis Grant/research funds Other; Bayer Grant/research funds Other; Otsuka Grant/research funds None; Bristol Myers Squibb Grant/research funds Other; Scynexis None None; Salix Grant/research funds Other; MannKind Other

Sandeep Mukherjee, MB, BCh, MPH, FRCPC Associate Professor, Department of Internal Medicine, Section of Gastroenterology and Hepatology, University of Nebraska Medical Center; Consulting Staff, Section of Gastroenterology and Hepatology, Veteran Affairs Medical Center

Sandeep Mukherjee, MB, BCh, MPH, FRCPC is a member of the following medical societies: Royal College of Physicians and Surgeons of Canada

Disclosure: Merck Honoraria Speaking and teaching; Ikaria Pharmaceuticals Honoraria Board membership

Shivkumar Prabhu, MD Consulting Staff, Department of Internal Medicine, St John Detroit Riverview Hospital

Disclosure: Nothing to disclose.

Daniel Schafer Department of Surgery, University of Nebraska Medical Center

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

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