Endocardial Cushion Defects (Atrioventricular Canal Defects, Atrioventricular Septal Defects) Medication

Updated: Dec 28, 2020
  • Author: Mary C Mancini, MD, PhD, MMM; Chief Editor: Yasmine S Ali, MD, MSCI, FACC, FACP  more...
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Medication Summary

Digitalis and diuretics are used to control the volume overload encountered in these patients until palliative or corrective surgery can be undertaken.

Digitalis provides myocardial support during the postoperative period and can be discontinued after 2-3 years.

Generally, the diuretic furosemide is prescribed for several months after repair in order to correct volume overload; it is discontinued once euvolemia is reached.



Class Summary

These agents are used to decrease volume overload.

Furosemide (Lasix)

Increases excretion of water by interfering with chloride-binding co-transport system, which in turn results inhibits sodium and chloride reabsorption in ascending loop of Henle and distal renal tubule.


Inotropic agents

Class Summary

These agents provide myocardial support in the perioperative period for patients with heart failure. The more restrictive the connection between the proximal and distal chambers, the more likely inotropic support will be required. A number of agents are available in this category.

Digoxin (Lanoxin)

Acts directly on cardiac muscle, increasing myocardial systolic contractions. Its indirect actions result in increased carotid sinus nerve activity and enhanced sympathetic withdrawal for any given increase in mean arterial pressure.