Bocavirus Clinical Presentation

Updated: Apr 25, 2018
  • Author: Pradeep Kumar Mada, MD, MRCP(UK); Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD  more...
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Dina et al (2009) reported that the main symptoms of human bocavirus (HBoV) infection in children include rhinitis, cough, dyspnea, wheezing, fever, and diarrhea. [32]

Symptoms of bocavirus infection in adults mimic those of atypical pneumonia, bronchitis, or acute exacerbations of chronic bronchitis in the respiratory tract and those of other causes of acute gastroenteritis in the gastrointestinal tract.

Human bocavirus is an emerging human parvovirus, and the full spectrum of disease associated with the virus remains to be seen.



HBoV infection can be asymptomatic or can manifest as GI or respiratory symptoms. The principal symptoms found included the following: [14]

  • Cough (almost 100% of patients)
  • Sputum (approximately 75%)
  • Diarrhea (approximately 30%)
  • Bronchitis (9%)
  • Asthma exacerbation (14%)
  • URTI (17%)
  • Wheezing (34%)
  • Pneumonia (73%)

Findings of bocavirus infection are similar to those of a typical viral respiratory illness or atypical pneumonia, including the following:

  • Fever

  • Rhinorrhea

  • Pertussislike cough

  • Wheezing

  • Tachypnea

  • Grunting

  • Accessory muscle use

In patients with acute bocavirus-associated gastroenteritis, findings may include the following:

  • Decreased perfusion with increased capillary refill time

  • Orthostatic changes

  • Minimal abdominal tenderness

  • Other signs associated with dehydration