Fixed Drug Eruptions Medication

Updated: Oct 09, 2020
  • Author: David F Butler, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

Lesions of fixed drug eruption resolve spontaneously with avoidance of the inciting drug. Additional medications should be used to relieve symptoms associated with the condition. Generally, an oral antihistamine (eg, hydroxyzine) and a topical corticosteroid may be sufficient. The use of corticosteroids may interfere with later diagnostic provocation testing. Hyperpigmentation may take many months to resolve. Incontinent pigment in the dermis responds poorly to topical bleaching agents such as hydroquinones.