Optic Nerve Sheath Meningioma Medication

Updated: May 11, 2021
  • Author: Mitchell V Gossman, MD; Chief Editor: Edsel B Ing, MD, PhD, MBA, MEd, MPH, MA, FRCSC  more...
  • Print

Medication Summary

The use of antihormonal agents in treating meningiomas is in anecdotal reports. Medical treatment is reserved for atypical and malignant meningiomas as an adjunct to surgery, partially resected benign meningiomas, and recurrence of meningiomas after a surgical resection.

Tamoxifen, an antiestrogen hormone, has been reported in a handful of patients with refractory or unresectable meningiomas; in one study by De Monte, the use of this agent resulted in stabilization of 6 out of 9 cases. [23]


Estrogen receptor antagonists

Class Summary

Inhibit estrogen effects by competitively binding to the estrogen receptor.

Tamoxifen (Nolvadex)

Competitively binds to the estrogen receptor, producing a nuclear complex that decreases DNA synthesis and inhibits estrogen effects.


Progesterone antagonists

Class Summary

RU-486 has been used experimentally to treat this medical condition.

RU-486 (Mifepristone)

Used experimentally in patients with recurrent benign meningiomas; in one study, tumor regression was reported in 5 out of 14 patients.