Intraocular Lens (IOL) Dislocation Medication

Updated: May 12, 2021
  • Author: Lihteh Wu, MD; Chief Editor: John D Sheppard, Jr, MD, MMSc  more...
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Medication Summary

Pilocarpine hydrochloride sometimes can be used as a trial medication to evaluate symptoms related to edge glare and optical aberrations secondary to IOL decentration.



Class Summary

For temporary pupillary constriction to relieve symptoms of optical aberrations.

Pilocarpine HCL (Akarpine, Ocusert Pilo-40, Pilostat, Piloptic, Salagen)

Pilocarpine, with a chemical name of (3S-cis)-2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H -imidazol-5-yl)methyl], monohydrochloride, has a molecular weight of 244.72. Pilocarpine HCl ophthalmic solution is a sterile solution for ophthalmic administration having the following composition: a direct-acting cholinergic parasympathomimetic agent, which acts through direct stimulation of muscarinic neuroreceptors and smooth muscle such as the iris and secretory glands. Pilocarpine produces miosis through contraction of the iris sphincter, causing increased tension on the scleral spur and opening of the trabecular meshwork spaces to facilitate outflow of aqueous humor. Outflow resistance is thereby reduced, lowering intraocular pressure.