Uveitis, Anterior, Childhood Workup

Updated: May 21, 2021
  • Author: Manolette R Roque, MD, MBA, FPAO; Chief Editor: John D Sheppard, Jr, MD, MMSc  more...
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Laboratory Studies

If JIA is suspected, obtain an antinuclear antibody test to classify the condition and to determine the risk of recurrent and severe disease.

In patients suspected of having AS, reactive arthritis, or inflammatory bowel disease, perform testing for the HLA-B27 haplotype. Sacroiliac joint films may demonstrate evidence of joint involvement in AS and reactive arthritis.

Sarcoid uveitis is investigated with determination of the angiotensin-converting enzyme (ACE) level, with or without serum lysozyme testing, chest roentgenograms, and gallium scanning. Remember that normal ACE values in children are higher than those in adults. Definitive diagnosis requires histopathologic demonstration of noncaseating granulomatous inflammation, in the absence of another possible cause.

If symptoms suggest TINU, urinalysis, serum creatinine, and urine beta-2-microglubulin testing is indicated.

Antistreptococcal lysin O titers are indicated in patients with possible poststreptococcal syndrome uveitis.


Imaging Studies

Laser Flare Photometry

Laser Flare Photometry (LFP) is a procedure that measures scattered light from a laser beam into the anterior chamber of an eye. The objective is to measure the amount and size of proteins and cells in the anterior chamber fluid (aqueous humor), serving as an indirect measure (biomarker) of ocular inflammation. [17, 18]

LFP may prove useful as a biomarker for anterior uveitis activity and response to treatment.