Growth Hormone Deficiency in Adults Medication

Updated: Jun 17, 2022
  • Author: Mohsen S Eledrisi, MD, FACP, FACE; Chief Editor: George T Griffing, MD  more...
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Growth Hormone Analogs

Class Summary

Recombinant growth hormone analogs are indicated for replacement therapy in patients with growth hormone deficiency.

Somatropin (Genotropin, Humatrope)

Human recombinant growth hormone is produced by recombinant deoxyribonucleic acid (DNA) technology. It stimulates the growth of linear bone, skeletal muscle, and organs and stimulates erythropoietin, increasing red blood cell mass. Actions are either direct or from the hepatic production of IGF-I. It is currently widely available in subcutaneous injection form. 

Somapacitan (Sogroya, somapacitan-beco)

Long-acting growth hormone indicated for replacement in adults with growth hormone deficiency. Administered by SC injection once-weekly.


Diagnostic Agents

Class Summary

Macimorelin is the first oral test available for diagnosis of GH deficiency.

Macimorelin (Macrilen)

Macimorelin is an oral ghrelin agonist. Ghrelin is a neuropeptide released mainly from cells in the stomach and pancreas in response to hunger and is a growth hormone-releasing peptide. It stimulates GH release by activating GH secretagogue receptors present in the pituitary and hypothalamus. Macimorelin is indicated for diagnosis of adult growth hormone deficiency.