Ophthalmologic Manifestations of Botulism Medication

Updated: May 16, 2022
  • Author: Bhupendra C K Patel, MD, FRCS; Chief Editor: Hampton Roy, Sr, MD  more...
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Medication Summary

Antitoxin appears to be the only effective medication. Guanethidine has been used and shown to be ineffective, despite reports of improvement in accommodative paresis.

In infant botulism, intravenous therapy with botulism immune globulin (BIG), which was approved by the US Food and Drug Administration (FDA) in 2003, is recommended to shorten the duration and to diminish the potential complications. [21]



Class Summary

Trivalent (types A, B, and E) equine botulism antitoxin should be used in the presence of foodborne botulism.

Botulinum antitoxin

Intravenous administration of one vial of botulism antitoxin results in serum levels of type A, B, and E antibodies capable of neutralizing serum toxin concentrations in excess of those reported for botulism patients. Circulating antitoxins have a half-life of 5-8 days.