Pellucid Marginal Degeneration (PMD) Follow-up

Updated: Oct 30, 2017
  • Author: Jean Deschênes, MD, FRCSC; Chief Editor: Hampton Roy, Sr, MD  more...
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Further Outpatient Care

Patients with pellucid marginal degeneration should receive follow-up care as needed.



Corneal hydrops similar to that seen in keratoconus, with disruption of the endothelial basement membrane and hydration of the adjacent corneal stroma, rarely occurs in pellucid marginal degeneration (PMD). [20]

Spontaneous corneal perforations in cases of pellucid marginal degeneration are rare. A few case reports have been published in the literature. [20, 21, 22]



No large-scale longitudinal studies of pellucid marginal degeneration have been reported. Quantifying the proportion of patients who eventually require surgery is difficult. Contact lens fitting and surgical correction are more difficult with pellucid marginal degeneration than with keratoconus.

In a follow-up of their ongoing longitudinal study of keratoconus, Rabinowitz and Rasheed have observed 31 patients with pellucid marginal degeneration up to 8 years. [23]  Five patients have required corneal transplantation in 1 eye, and one patient has required transplantation in both eyes. The data must be interpreted with caution because these observations may have been affected by selection bias.