Giant Papillary Conjunctivitis Differential Diagnoses

Updated: Jan 24, 2023
  • Author: Karen K Yeung, OD, FAAO; Chief Editor: John D Sheppard, Jr, MD, MMSc  more...
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Diagnostic Considerations

Distinguish giant papillary conjunctivitis (GPC) from the following conditions:

  • Other diseases that cause conjunctivitis and ocular itching/mucus - Typically ocular allergies (seasonal allergic conjunctivitis) but also viral and bacterial conjunctivitis and blepharitis
  • Other diseases that cause papillary changes in the tarsal conjunctiva of the lids, especially vernal and atopic conjunctivitis
  • Other giant papillary–forming disorders based on the creamy white appearance of the giant papillae center/top
  • Other diseases that cause follicular changes, which can easily be confused with papillary changes, in the palpebral conjunctivae of the lids - Viral conjunctivitis (adenovirus and herpes), chlamydial infections, and Gel-Coombs type IV hypersensitivity and toxic reactions, particularly to contact lens solutions and other medications (eg, brimonidine) [18]
  • Other causes of contact lens intolerance, such as poor fit, dry eyes, and blepharitis

Differential Diagnoses