Khan S, Al Baradie R. Epileptic encephalopathies: an overview. Epilepsy Res Treat. 2012. 2012:403592. [QxMD MEDLINE Link]. [Full Text].
Kural Z, Ozer AF. Epileptic encephalopathies in adults and childhood. Epilepsy Res Treat. 2012. 2012:205131. [QxMD MEDLINE Link]. [Full Text].
Engel J Jr. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001 Jun. 42(6):796-803. [QxMD MEDLINE Link].
Drislane FW. Overlap of Encephalopathies and Epileptic Seizures. J Clin Neurophysiol. 2013 Oct. 30(5):468-476. [QxMD MEDLINE Link].
Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde Boas W, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010 Apr. 51 (4):676-85. [QxMD MEDLINE Link].
Coppola G, Plouin P, Chiron C, Robain O, Dulac O. Migrating partial seizures in infancy: a malignant disorder with developmental arrest. Epilepsia. 1995 Oct. 36(10):1017-24. [QxMD MEDLINE Link].
A glossary of terms most commonly used by clinical electroencephalographers. Electroencephalogr Clin Neurophysiol. 1974 Nov. 37(5):538-48. [QxMD MEDLINE Link].
Moruzzi G, Magoun HW. Brain stem reticular formation and activation of the EEG. 1949. J Neuropsychiatry Clin Neurosci. 1995 Spring. 7(2):251-67. [QxMD MEDLINE Link].
Holmes GL, Lenck-Santini PP. Role of interictal epileptiform abnormalities in cognitive impairment. Epilepsy Behav. 2006 May. 8(3):504-15. [QxMD MEDLINE Link].
Shewmon DA, Erwin RJ. Transient impairment of visual perception induced by single interictal occipital spikes. J Clin Exp Neuropsychol. 1989 Oct. 11(5):675-91. [QxMD MEDLINE Link].
Shewmon DA, Erwin RJ. The effect of focal interictal spikes on perception and reaction time. II. Neuroanatomic specificity. Electroencephalogr Clin Neurophysiol. 1988 Apr. 69(4):338-52. [QxMD MEDLINE Link].
Kasteleijn-Nolst Trenité DG. Transient cognitive impairment during subclinical epileptiform electroencephalographic discharges. Semin Pediatr Neurol. 1995 Dec. 2(4):246-53. [QxMD MEDLINE Link].
Aarts JH, Binnie CD, Smit AM, Wilkins AJ. Selective cognitive impairment during focal and generalized epileptiform EEG activity. Brain. 1984 Mar. 107 ( Pt 1):293-308. [QxMD MEDLINE Link].
Binnie CD. Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?. Lancet Neurol. 2003 Dec. 2(12):725-30. [QxMD MEDLINE Link].
Binnie CD. Significance and management of transitory cognitive impairment due to subclinical EEG discharges in children. Brain Dev. 1993 Jan-Feb. 15(1):23-30. [QxMD MEDLINE Link].
Binnie CD, Kasteleijn-Nolst Trenité DG, Smit AM, Wilkins AJ. Interactions of epileptiform EEG discharges and cognition. Epilepsy Res. 1987 Jul. 1(4):239-45. [QxMD MEDLINE Link].
Aldenkamp AP, Overweg J, Gutter T, Beun AM, Diepman L, Mulder OG. Effect of epilepsy, seizures and epileptiform EEG discharges on cognitive function. Acta Neurol Scand. 1996 Apr. 93(4):253-9. [QxMD MEDLINE Link].
Nicolai J, Aldenkamp AP, Arends J, Weber JW, Vles JS. Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy Behav. 2006 Feb. 8(1):56-70. [QxMD MEDLINE Link].
Massa R, de Saint-Martin A, Carcangiu R, Rudolf G, Seegmuller C, Kleitz C, et al. EEG criteria predictive of complicated evolution in idiopathic rolandic epilepsy. Neurology. 2001 Sep 25. 57(6):1071-9. [QxMD MEDLINE Link].
Nabbout R, Dulac O. Epileptic encephalopathies: a brief overview. J Clin Neurophysiol. 2003 Nov-Dec. 20(6):393-7. [QxMD MEDLINE Link].
Morrell F. Secondary epileptogenesis in man. Arch Neurol. 1985 Apr. 42(4):318-35. [QxMD MEDLINE Link].
Morrell F, Whisler WW, Smith MC, Hoeppner TJ, de Toledo-Morrell L, Pierre-Louis SJ, et al. Landau-Kleffner syndrome. Treatment with subpial intracortical transection. Brain. 1995 Dec. 118 ( Pt 6):1529-46. [QxMD MEDLINE Link].
Kobayashi K, Murakami N, Yoshinaga H, Enoki H, Ohtsuka Y, Ohtahara S. Nonconvulsive status epilepticus with continuous diffuse spike-and-wave discharges during sleep in childhood. Jpn J Psychiatry Neurol. 1988 Sep. 42(3):509-14. [QxMD MEDLINE Link].
Guzzetta F, Battaglia D, Veredice C, Donvito V, Pane M, Lettori D, et al. Early thalamic injury associated with epilepsy and continuous spike-wave during slow sleep. Epilepsia. 2005 Jun. 46(6):889-900. [QxMD MEDLINE Link].
Sánchez Fernández I, Takeoka M, Tas E, Peters JM, Prabhu SP, Stannard KM, et al. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29. 78 (22):1721-7. [QxMD MEDLINE Link].
Hrachovy RA, Frost JD. Severe Encephalopathic Epilepsy in Infants: Infantile Spasms (West Syndrome). In: Pellock JM, Bourgeois BFD, Dodson WE. Undefined. Pediatric Epilepsy. Third Edition. New York, NY: Demos Medical Publishing; 2008:16.
Saitoh M, Shinohara M, Hoshino H, Kubota M, Amemiya K, Takanashi JL, et al. Mutations of the SCN1A gene in acute encephalopathy. Epilepsia. 2012 Feb 6. [QxMD MEDLINE Link].
} Dalla Bernardina B, Fontana E, Darra F. Myoclonic status in non-progressive encephalopathies. International Leauge Against Epilepsy. Available at http://www.ilae.org/ctf/myoclon_stat_nonpro_enceph.html. Accessed: February 15, 2011.
Morita DA, Glauser TA. Lennox-Gastaut Syndrome. In: Pellock JM, Bourgeois BFD, Dodson E. Third. Undefined. Pediatric Epilepsy: Diagnosis and Therapy. New York, NY: Demos Medical Publishing; 2008:Chapter 21.
Takeoka M, Riviello JJ Jr, Duffy FH, Kim F, Kennedy DN, Makris N, et al. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 2004 Oct 12. 63(7):1289-92. [QxMD MEDLINE Link].
Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, et al. Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). Eur J Hum Genet. 2009 Sep. 17(9):1171-81. [QxMD MEDLINE Link]. [Full Text].
Deonna T, Roulet E. Autistic spectrum disorder: evaluating a possible contributing or causal role of epilepsy. Epilepsia. 2006. 47 Suppl 2:79-82. [QxMD MEDLINE Link].
Kramer U, Nevo Y, Neufeld MY, Fatal A, Leitner Y, Harel S. Epidemiology of epilepsy in childhood: a cohort of 440 consecutive patients. Pediatr Neurol. 1998 Jan. 18(1):46-50. [QxMD MEDLINE Link].
Aicardi J, Ohtahara S. Severe neonatal epilepsies with suppression-burst pattern. In: Roger J, Thomas P, Bureau M, Hirsch D, Dravet C, et al. Undefined. Syndromes in Infancy, Childhood and Adolescence. Fourth Edition. John Libbey Eurotext; 2005:Chapter 3.
Hurst DL. Epidemiology of severe myoclonic epilepsy of infancy. Epilepsia. 1990 Jul-Aug. 31(4):397-400. [QxMD MEDLINE Link].
Guerrini R, Parmeggiani L, Bonanni P, Kaminska A, Dulac O. Myoclonic astatic epilepsy. In: Roger J, Bureau M, et al. Undefined. Syndromes in Infancy, Childhood and Adolescence. Fourth Edition. Montrouge, France: John Libbey Eurotext; 2005:Chapter 8.
Oguni H, Hayashi K, Imai K, Funatsuka M, Sakauchi M, Shirakawa S, et al. Idiopathic myoclonic-astatic epilepsy of early childhood--nosology based on electrophysiologic and long-term follow-up study of patients. Adv Neurol. 2005. 95:157-74. [QxMD MEDLINE Link].
Oguni H, Hayashi K, Osawa M. Long-term prognosis of Lennox-Gastaut syndrome. Epilepsia. 1996. 37 Suppl 3:44-7. [QxMD MEDLINE Link].
Weglage J, Demsky A, Pietsch M, Kurlemann G. Neuropsychological, intellectual, and behavioral findings in patients with centrotemporal spikes with and without seizures. Dev Med Child Neurol. 1997 Oct. 39(10):646-51. [QxMD MEDLINE Link].
Staden U, Isaacs E, Boyd SG, Brandl U, Neville BG. Language dysfunction in children with Rolandic epilepsy. Neuropediatrics. 1998 Oct. 29(5):242-8. [QxMD MEDLINE Link].
Nicolai J, van der Linden I, Arends JB, van Mil SG, Weber JW, Vles JS, et al. EEG characteristics related to educational impairments in children with benign childhood epilepsy with centrotemporal spikes. Epilepsia. 2007 Nov. 48(11):2093-100. [QxMD MEDLINE Link].
Saint-Martin AD, Seegmuller C, Carcangiu R, Kleitz C, Hirsch E, Marescaux C, et al. [Cognitive consequences of Rolandic Epilepsy]. Epileptic Disord. 2001. 3 Spec No 2:SI59-65. [QxMD MEDLINE Link].
Metz-Lutz MN, Filippini M. Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome. Epilepsia. 2006. 47 Suppl 2:71-5. [QxMD MEDLINE Link].
Ohtahara S, Yamatogi Y. Ohtahara syndrome: with special reference to its developmental aspects for differentiating from early myoclonic encephalopathy. Epilepsy Res. 2006 Aug. 70 Suppl 1:S58-67. [QxMD MEDLINE Link].
McKinney W, McGreal DA. An aphasic syndrome in children. Can Med Assoc J. 1974 Mar 16. 110(6):637-9. [QxMD MEDLINE Link]. [Full Text].
Riviello JJ, Hadjiloizou S. The Landau-Kleffner Syndrome and Continuous Spike-Waves during Sleep. In: Pellock JM, Bourgeois BFD, Dodson WE. Pediatric Epilepsy: Diagnosis and Therapy. Third Edition. New York, NY: Demos Medical Publishing; 2008:Chapter 24.
Tuchman R, Rapin I. Epilepsy in autism. Lancet Neurol. 2002 Oct. 1(6):352-8. [QxMD MEDLINE Link].
Levisohn PM. The autism-epilepsy connection. Epilepsia. 2007. 48 Suppl 9:33-5. [QxMD MEDLINE Link].
Laufs H. Functional imaging of seizures and epilepsy: evolution from zones to networks. Curr Opin Neurol. 2012 Feb 8. [QxMD MEDLINE Link].
Wong-Kisiel LC, Nickels K. Electroencephalogram of Age-Dependent Epileptic Encephalopathies in Infancy and Early Childhood. Epilepsy Res Treat. 2013. 2013:743203. [QxMD MEDLINE Link]. [Full Text].
Patry G, Lyagoubi S, Tassinari CA. Subclinical "electrical status epilepticus" induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol. 1971 Mar. 24(3):242-52. [QxMD MEDLINE Link].
Van Hirtum-Das M, Licht EA, Koh S, Wu JY, Shields WD, Sankar R. Children with ESES: variability in the syndrome. Epilepsy Res. 2006 Aug. 70 Suppl 1:S248-58. [QxMD MEDLINE Link].
Smith MC, Hoeppner TJ. Epileptic encephalopathy of late childhood: Landau-Kleffner syndrome and the syndrome of continuous spikes and waves during slow-wave sleep. J Clin Neurophysiol. 2003 Nov-Dec. 20(6):462-72. [QxMD MEDLINE Link].
[Guideline] Hirtz D, Ashwal S, Berg A, Bettis D, Camfield C, Camfield P, et al. Practice parameter: evaluating a first nonfebrile seizure in children: report of the quality standards subcommittee of the American Academy of Neurology, The Child Neurology Society, and The American Epilepsy Society. Neurology. 2000 Sep 12. 55(5):616-23. [QxMD MEDLINE Link].
[Guideline] Karis JP, Seidenwurm DJ, Davis PC, Brunberg JA, De La Paz RL, Dormont PD, et al. ACR Appropriateness Criteria epilepsy. Epilepsy. [Full Text].
Cusmai R, Martinelli D, Moavero R, Dionisi Vici C, Vigevano F, Castana C, et al. Ketogenic diet in early myoclonic encephalopathy due to non ketotic hyperglycinemia. Eur J Paediatr Neurol. 2012 Jan 17. [QxMD MEDLINE Link].
Chiron C, Marchand MC, Tran A, Rey E, d'Athis P, Vincent J, et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet. 2000 Nov 11. 356(9242):1638-42. [QxMD MEDLINE Link].
Sasagawa M, Kioi Y. [A successful treatment with intravenous high doses of gamma globulin for a minor status in a patient with Doose syndrome]. No To Hattatsu. 1997 May. 29(3):261-3. [QxMD MEDLINE Link].
LANDAU WM, KLEFFNER FR. Syndrome of acquired aphasia with convulsive disorder in children. Neurology. 1957 Aug. 7(8):523-30. [QxMD MEDLINE Link].
Deuel RK, Lenn NJ. Treatment of acquired epileptic aphasia. J Pediatr. 1977 Jun. 90(6):959-61. [QxMD MEDLINE Link].
Aeby A, Poznanski N, Verheulpen D, Wetzburger C, Van Bogaert P. Levetiracetam efficacy in epileptic syndromes with continuous spikes and waves during slow sleep: experience in 12 cases. Epilepsia. 2005 Dec. 46(12):1937-42. [QxMD MEDLINE Link].
De Negri M, Baglietto MG, Battaglia FM, Gaggero R, Pessagno A, Recanati L. Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test. Brain Dev. 1995 Sep-Oct. 17(5):330-3. [QxMD MEDLINE Link].
Hadjiloizou SM, Bourgeois BFD, Duffy FH, et al. Childhood-onset epileptic encephalopathies with sleep activated EEG (EESA_EEG) and high dose diazepam treatment (HDDT): Review of a 5-year experience at Children's Hospital Boston. Undefined. Epilepsia. Suppl. 8; 2005;46:150-151.
Marescaux C, Hirsch E, Finck S, Maquet P, Schlumberger E, Sellal F, et al. Landau-Kleffner syndrome: a pharmacologic study of five cases. Epilepsia. 1990 Nov-Dec. 31(6):768-77. [QxMD MEDLINE Link].
Lerman P, Lerman-Sagie T, Kivity S. Effect of early corticosteroid therapy for Landau-Kleffner syndrome. Dev Med Child Neurol. 1991 Mar. 33(3):257-60. [QxMD MEDLINE Link].
Chez MG, Loeffel M, Buchanan CP, et al. Pulse high-dose steroids as combination therapy with valproic acid in epileptic aphasia patients with pervasive developmental delay or autism. Undefined. Ann Neurol. 1998;44(3):539.
Tsuru T, Mori M, Mizuguchi M, Momoi MY. Effects of high-dose intravenous corticosteroid therapy in Landau-Kleffner syndrome. Pediatr Neurol. 2000 Feb. 22(2):145-7. [QxMD MEDLINE Link].
Sinclair DB, Snyder TJ. Corticosteroids for the treatment of Landau-kleffner syndrome and continuous spike-wave discharge during sleep. Pediatr Neurol. 2005 May. 32(5):300-6. [QxMD MEDLINE Link].
Ztalmy (ganaxolone) [package insert]. Pador, PA: Marinus Pharmaceuticals, Inc. March 2022. Available at [Full Text].
Dagar A, Chandra PS, Chaudhary K, Avnish C, Bal CS, Gaikwad S, et al. Epilepsy Surgery in a Pediatric Population: A Retrospective Study of 129 Children from a Tertiary Care Hospital in a Developing Country along with Assessment of Quality of Life. Pediatr Neurosurg. 2011. 47(3):186-93. [QxMD MEDLINE Link].
Morrell F, Whisler WW, Bleck TP. Multiple subpial transection: a new approach to the surgical treatment of focal epilepsy. J Neurosurg. 1989 Feb. 70(2):231-9. [QxMD MEDLINE Link].
Grote CL, Van Slyke P, Hoeppner JA. Language outcome following multiple subpial transection for Landau-Kleffner syndrome. Brain. 1999 Mar. 122 ( Pt 3):561-6. [QxMD MEDLINE Link].
Irwin K, Birch V, Lees J, Polkey C, Alarcon G, Binnie C, et al. Multiple subpial transection in Landau-Kleffner syndrome. Dev Med Child Neurol. 2001 Apr. 43(4):248-52. [QxMD MEDLINE Link].