Overview
What is Lambert-Eaton myasthenic syndrome (LEMS)?
What is the pathophysiology of Lambert-Eaton myasthenic syndrome (LEMS)?
What causes Lambert-Eaton myasthenic syndrome (LEMS)?
What causes Lambert-Eaton myasthenic syndrome (LEMS)?
What is the epidemiology of Lambert-Eaton myasthenic syndrome (LEMS) in the US?
What are the demographics of Lambert-Eaton myasthenic syndrome (LEMS)?
What is the prognosis of Lambert-Eaton myasthenic syndrome (LEMS)?
Presentation
What are the symptoms of Lambert-Eaton myasthenic syndrome (LEMS)?
What are other symptoms of Lambert-Eaton myasthenic syndrome (LEMS)?
What is the relationship between cancer and Lambert-Eaton myasthenic syndrome (LEMS)?
What are the physical findings in Lambert-Eaton myasthenic syndrome (LEMS)?
DDX
What are the diagnostic considerations of Lambert-Eaton myasthenic syndrome (LEMS)?
What are the differential diagnoses for Lambert-Eaton Myasthenic Syndrome (LEMS)?
Workup
What are the approach considerations in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?
How is needle electromyography used in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?
How is single-fiber electromyography used in the workup of Lambert-Eaton myasthenic syndrome (LEMS)?
Treatment
What are the treatment approach considerations in Lambert-Eaton myasthenic syndrome (LEMS)?
What is the initial management of Lambert-Eaton myasthenic syndrome (LEMS)?
Which medications should be avoided in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?
What is the approach to cancer workup and treatment in Lambert-Eaton myasthenic syndrome (LEMS)?
Which medications are used in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?
What long-term monitoring is indicated in the treatment of Lambert-Eaton myasthenic syndrome (LEMS)?
Medications
What is the drug treatment for Lambert-Eaton myasthenic syndrome (LEMS)?
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Characteristic responses to repetitive nerve stimulation in patient with Lambert-Eaton myasthenic syndrome. (A) Responses elicited from hand muscle by stimulation of nerve at 3 Hz. Amplitude of initial response is less than normal, and response is decremental. (B) Responses as in A, immediately after voluntary activation of muscle for 10 seconds. Amplitude has increased. (C) Responses in hand muscle elicited by 20-Hz stimulation of nerve for 10 seconds. Response amplitude is less than normal initially, falls further during first few stimuli, then increases and ultimately becomes more than twice initial value.
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Compound muscle action potentials elicited from hand muscle before and immediately after maximal voluntary activation of muscle for 10 seconds. Amplitude is small initially, increasing almost 10 times after activation.