Central Nervous System Lymphoma in HIV Clinical Presentation

Updated: Feb 13, 2018
  • Author: Florian P Thomas, MD, PhD, MA, MS; Chief Editor: Niranjan N Singh, MBBS, MD, DM, FAHS, FAANEM  more...
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History and Physical Examination

The onset of CNS lymphoma is often more insidious than that of CNS toxoplasmosis. Presenting symptoms may include lethargy, confusion, impaired memory, headache, seizures, or focal weakness.

Lethargy, confusion, impaired memory, and focal neurologic signs may be noted on physical examination. Fever is usually absent. Funduscopy may reveal ocular involvement. Ocular involvement is seen in up to 20% of the patients, and a slit-lamp examination should be performed in these patients.