Marchiafava-Bignami Disease Differential Diagnoses

Updated: Jun 27, 2017
  • Author: Cortney Lyford, MD; Chief Editor: Tarakad S Ramachandran, MBBS, MBA, MPH, FAAN, FACP, FAHA, FRCP, FRCPC, FRS, LRCP, MRCP, MRCS  more...
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Diagnostic Considerations

The corpus callosum may also be affected in other diseases such as ischemic stroke, ateriovenous malformations, diffuse axonal injury, CNS lymphoma, progressive multifocal leukoencephalopathy, and multiple sclerosis. However, Marchiafava-Bignami disease (MBD) is distinguished by callosal lesions that are usually symmetrical and located in the middle of the corpus callosum. Certainly, one should consider Wernicke-Korsakoff in alcoholic patients with acute or subacute mental status changes, though MRI typically reveals increased T2/FLAIR signal involving the mamillary bodies, dorsomedial thalami, tectal plate, periaqueductal area, and around the third ventricle.

Differential Diagnoses