Intra-articular Methylene Blue Injection Periprocedural Care

Updated: Apr 12, 2021
  • Author: Gil Z Shlamovitz, MD, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Periprocedural Care


Equipment used for intra-articular injection of methylene blue includes the following:

  • Sterile preparation solution and surgical scrubs
  • Sterile drapes
  • Sterile gloves
  • Sterile bowl
  • Normal saline bottle (~500 mL)
  • Sterile methylene blue or fluorescein dye
  • Syringes, 12 mL and 20 or 30 mL
  • Needles, 18 and 21 gauge
  • Local anesthetic solution
  • Sterile 4 × 4 gauze pads

Patient Preparation


For anesthesia, inject a local anesthetic agent such as 1% lidocaine subcutaneously until a skin wheal appears before entering the joint space. For more information, see Infiltrative Administration of Local Anesthetic Agents.


Positioning varies according to the joint that is to undergo injection.