Dermatologic Manifestations of Generalized Lipodystrophy Workup

Updated: Apr 16, 2021
  • Author: Camila K Janniger, MD; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

Generalized congenital lipodystrophy often affects the cardiovascular system, tending to be linked with metabolic abnormalities involving glycidic and lipid metabolisms. Cardiovascular and metabolic abnormalities should be evaluated in young asymptomatic individuals with generalized congenital lipodystrophy, in whom a high prevalence was documented in one study, pointing to the need for systematic cardiovascular preventive measures in this high-risk group. [17]


Imaging Studies

Radiographic features include advanced skeletal age, bone cysts, and dilated cerebral ventricles and basal cisterns on pneumoencephalography. Basal cisterns on pneumoencephalography correlated with other findings, demonstrating a high incidence of hypothalamic enlargement and possibly correlating with the tendency of patients with generalized lipodystrophy to have below-average intelligence.

Subcutaneous fat in lipodystrophy types can be quantified by magnetic resonance imaging. [18]