Hyperkeratosis Lenticularis Perstans (Flegel Disease) Medication

Updated: Nov 11, 2021
  • Author: Daniel Roling, MD; Chief Editor: William D James, MD  more...
  • Print

Medication Summary

These medications have proven the most efficacious for the treatment of hyperkeratosis lenticularis perstans (Flegel disease).


Topical cytotoxic agents

Class Summary

Inhibit cell growth and proliferation.

Fluorouracil topical (Efudex, Fluoroplex)

Fluorouracil has been in clinical use since the 1960s. Systemic absorption is limited to approximately 6% of the applied dose and is selectively higher in abnormal skin. Fluorouracil interferes with pyrimidine metabolism by inhibiting thymidylate synthetase, thus inhibiting DNA synthesis.

It is available as 5% (Efudex) or 1% (Fluoroplex) cream, 2% or 5% solution (both Efudex), or 1% solution (Fluoroplex).

If applied with the fingers, wash hands immediately after application.

Fluorouracil is FDA approved for the treatment of actinic keratosis and superficial basal cell carcinomas.



Class Summary

Essential for normal DNA synthesis.

Calcipotriene (Dovonex)

Calcipotriene is a  synthetic vitamin D-3 derivative that possesses therapeutic properties similar to vitamin D-3, including inhibition of epidermal proliferation, induction of differentiation, and anti-inflammatory effects.