Acrodermatitis Enteropathica Treatment & Management

Updated: Jun 04, 2021
  • Author: Kristina Marie Dela Rosa, MD; Chief Editor: William D James, MD  more...
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Medical Care

Treatment of acrodermatitis enteropathica requires lifelong zinc supplementation. Typically, 1-3 mg/kg of zinc gluconate or sulfate is administered orally each day. [9, 15] Clinical improvement occurs prior to any significant change in the plasma zinc levels, usually within days to weeks of initiating treatment. Monitor serum zinc levels and alkaline phosphatase values every 3-6 months. [9]

Acrodermatitis enteropathica exacerbation during pregnancy or the stress of disease may require an increase in therapy. [1, 40]

Warm compresses to remove the scale crust, followed by application of white petrolatum to eroded skin lesions, may enhance reepithelialization when used concurrently with zinc replacement.



Although no special diet is required for acrodermatitis enteropathica patients, as long as zinc supplementation is continued, certain foods contain increased levels of zinc, including oysters, crab, beef, pork, and fowl. Zinc content is directly related to protein content. [24, 41]



No activity restrictions are necessary for acrodermatitis enteropathica patients.


Long-Term Monitoring

Outpatient follow-up care is critical for acrodermatitis enteropathica patients to ensure proper growth and development.